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Description
| - Synthetic caspase inhibitors and particularly broad- spectrum caspase inhibitors can prevent cells from death or at least slow down cell death process and abrogate some apoptotic hallmarks (Kitanaka and Kuchino 1999). However, not all synthetic caspase inhibitors diminish cell death. We have found that the broad spectrum caspase inhibitor Boc-Asp-CMK induced cell death at micromolar concentrations in human leukaemia cells. Interestingly, low concentrations of Boc-Asp-CMK induced cell death with apoptotic hallmarks. Increasing concentrations of Boc-Asp-CMK led to necrotic cell death. The switch between apoptosis and necrosis seemed to depend upon the degree of inhibition of executioner caspases, including caspase-3/7 with Boc-Asp-CMK. Interestingly, caspase-3 processing was not inhibited even for the highest concentration of Boc-Asp-CMK used. We assume that toxic properties of Boc-Asp-CMK can be attributed to the chloromethylketone residuum in its molecule, as its analogue Boc-Asp-FMK with fluoromethyl
- Synthetic caspase inhibitors and particularly broad- spectrum caspase inhibitors can prevent cells from death or at least slow down cell death process and abrogate some apoptotic hallmarks (Kitanaka and Kuchino 1999). However, not all synthetic caspase inhibitors diminish cell death. We have found that the broad spectrum caspase inhibitor Boc-Asp-CMK induced cell death at micromolar concentrations in human leukaemia cells. Interestingly, low concentrations of Boc-Asp-CMK induced cell death with apoptotic hallmarks. Increasing concentrations of Boc-Asp-CMK led to necrotic cell death. The switch between apoptosis and necrosis seemed to depend upon the degree of inhibition of executioner caspases, including caspase-3/7 with Boc-Asp-CMK. Interestingly, caspase-3 processing was not inhibited even for the highest concentration of Boc-Asp-CMK used. We assume that toxic properties of Boc-Asp-CMK can be attributed to the chloromethylketone residuum in its molecule, as its analogue Boc-Asp-FMK with fluoromethyl (en)
- Syntetické inhibitory kaspáz a z části také širokospektré kaspázové inhibitory mohou zabránit buněčné smrti nebo přinejmenším zpomalit proces buněčné smrti a zamezit některým apoptotickým projevům. (cs)
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Title
| - The broad-spectrum caspase inhibitor Boc-Asp-CMK induces cell death in human leukaemia cells
- Širokospektrý kaspázový inhibitor Boc-Asp-CMK indukuje buněčnou smrt u lidských leukemických buněk (cs)
- The broad-spectrum caspase inhibitor Boc-Asp-CMK induces cell death in human leukaemia cells (en)
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skos:prefLabel
| - The broad-spectrum caspase inhibitor Boc-Asp-CMK induces cell death in human leukaemia cells
- Širokospektrý kaspázový inhibitor Boc-Asp-CMK indukuje buněčnou smrt u lidských leukemických buněk (cs)
- The broad-spectrum caspase inhibitor Boc-Asp-CMK induces cell death in human leukaemia cells (en)
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skos:notation
| - RIV/61989592:15110/08:00007390!RIV09-MSM-15110___
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/61989592:15110/08:00007390
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - caspase-3 processing; cell respiration; apoptosis; necrosis; U937 cells (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
| - GB - Spojené království Velké Británie a Severního Irska
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Doležel, Petr
- Mlejnek, Petr
- Frydrych, Ivo
- Zoumpourlis, V.
- Krumpochová, Petra
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http://linked.open...n/vavai/riv/zamer
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issn
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number of pages
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http://localhost/t...ganizacniJednotka
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