About: The broad-spectrum caspase inhibitor Boc-Asp-CMK induces cell death in human leukaemia cells

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About: The broad-spectrum caspase inhibitor Boc-Asp-CMK induces cell death in human leukaemia cells Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Synthetic caspase inhibitors and particularly broad- spectrum caspase inhibitors can prevent cells from death or at least slow down cell death process and abrogate some apoptotic hallmarks (Kitanaka and Kuchino 1999). However, not all synthetic caspase inhibitors diminish cell death. We have found that the broad spectrum caspase inhibitor Boc-Asp-CMK induced cell death at micromolar concentrations in human leukaemia cells. Interestingly, low concentrations of Boc-Asp-CMK induced cell death with apoptotic hallmarks. Increasing concentrations of Boc-Asp-CMK led to necrotic cell death. The switch between apoptosis and necrosis seemed to depend upon the degree of inhibition of executioner caspases, including caspase-3/7 with Boc-Asp-CMK. Interestingly, caspase-3 processing was not inhibited even for the highest concentration of Boc-Asp-CMK used. We assume that toxic properties of Boc-Asp-CMK can be attributed to the chloromethylketone residuum in its molecule, as its analogue Boc-Asp-FMK with fluoromethyl Synthetic caspase inhibitors and particularly broad- spectrum caspase inhibitors can prevent cells from death or at least slow down cell death process and abrogate some apoptotic hallmarks (Kitanaka and Kuchino 1999). However, not all synthetic caspase inhibitors diminish cell death. We have found that the broad spectrum caspase inhibitor Boc-Asp-CMK induced cell death at micromolar concentrations in human leukaemia cells. Interestingly, low concentrations of Boc-Asp-CMK induced cell death with apoptotic hallmarks. Increasing concentrations of Boc-Asp-CMK led to necrotic cell death. The switch between apoptosis and necrosis seemed to depend upon the degree of inhibition of executioner caspases, including caspase-3/7 with Boc-Asp-CMK. Interestingly, caspase-3 processing was not inhibited even for the highest concentration of Boc-Asp-CMK used. We assume that toxic properties of Boc-Asp-CMK can be attributed to the chloromethylketone residuum in its molecule, as its analogue Boc-Asp-FMK with fluoromethyl (en) Syntetické inhibitory kaspáz a z části také širokospektré kaspázové inhibitory mohou zabránit buněčné smrti nebo přinejmenším zpomalit proces buněčné smrti a zamezit některým apoptotickým projevům. (cs)
Title	The broad-spectrum caspase inhibitor Boc-Asp-CMK induces cell death in human leukaemia cells Širokospektrý kaspázový inhibitor Boc-Asp-CMK indukuje buněčnou smrt u lidských leukemických buněk (cs) The broad-spectrum caspase inhibitor Boc-Asp-CMK induces cell death in human leukaemia cells (en)
skos:prefLabel	The broad-spectrum caspase inhibitor Boc-Asp-CMK induces cell death in human leukaemia cells Širokospektrý kaspázový inhibitor Boc-Asp-CMK indukuje buněčnou smrt u lidských leukemických buněk (cs) The broad-spectrum caspase inhibitor Boc-Asp-CMK induces cell death in human leukaemia cells (en)
skos:notation	RIV/61989592:15110/08:00007390!RIV09-MSM-15110___
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(MSM6198959216)
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2009
http://linked.open...aciTvurceVysledku	MLEJNEK, Petr Frydrych, Ivo
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Palackého v Olomouci / Lékařská fakulta
http://linked.open...dnocenehoVysledku	358525
http://linked.open...ai/riv/idVysledku	RIV/61989592:15110/08:00007390
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	caspase-3 processing; cell respiration; apoptosis; necrosis; U937 cells (en)
http://linked.open.../riv/klicoveSlovo	cell respiration necrosis apoptosis U937 cells caspase-3 processing
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[2D5F22121292]
http://linked.open...i/riv/nazevZdroje	Toxicology in Vitro
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...UplatneniVysledku	2008
http://linked.open...v/svazekPeriodika	22
http://linked.open...iv/tvurceVysledku	Doležel, Petr Mlejnek, Petr Frydrych, Ivo Zoumpourlis, V. Krumpochová, Petra
http://linked.open...n/vavai/riv/zamer	Modulation of signalling and regulatory pathways in normal and cancer cells
issn	0887-2333
number of pages	5 (xsd:int)
http://localhost/t...ganizacniJednotka	15110
is http://linked.open...avai/riv/vysledek of	The broad-spectrum caspase inhibitor Boc-Asp-CMK induces cell death in human leukaemia cells The broad-spectrum caspase inhibitor Boc-Asp-CMK induces cell death in human leukaemia cells The broad-spectrum caspase inhibitor Boc-Asp-CMK induces cell death in human leukaemia cells The broad-spectrum caspase inhibitor Boc-Asp-CMK induces cell death in human leukaemia cells

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