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| Description
| - The aim of this work was to study matrix metalloproteinase-26 (MMP-26) and tissue inhibitor of metalloproteinases-4 (TIMP-4) in the human endometrium. Both these enzymes may be implicated in the implantation process. Trophoblast tissue from human, as well as mice embryo produces pro-MMP-9. Active MMP-9 is a proteolytic enzyme with a broad substrate specificity. MMP-26 is an affective activator of pro-MMP-9, and TIMP-4 is a strong inhibitor of MMP-26. We have shown that the endometrial expression of MMP-26 and TIMP-4 genes is maximal in mid-cycle. The expression pattern of both genes suggests their up-regulation by estrogen, and down-regulation by progesterone. This is supported by our findings of estrogen response elements upstream the coding sequences of both genes. Our findings suggest that TIMP-4 is produced in the stroma only, secreted by stromal cells, taken up by epithelial cells, accumulated in apical granules, and finally secreted to the uterine fluid. Results of MMP-26 and TIMP-4 expression i
- The aim of this work was to study matrix metalloproteinase-26 (MMP-26) and tissue inhibitor of metalloproteinases-4 (TIMP-4) in the human endometrium. Both these enzymes may be implicated in the implantation process. Trophoblast tissue from human, as well as mice embryo produces pro-MMP-9. Active MMP-9 is a proteolytic enzyme with a broad substrate specificity. MMP-26 is an affective activator of pro-MMP-9, and TIMP-4 is a strong inhibitor of MMP-26. We have shown that the endometrial expression of MMP-26 and TIMP-4 genes is maximal in mid-cycle. The expression pattern of both genes suggests their up-regulation by estrogen, and down-regulation by progesterone. This is supported by our findings of estrogen response elements upstream the coding sequences of both genes. Our findings suggest that TIMP-4 is produced in the stroma only, secreted by stromal cells, taken up by epithelial cells, accumulated in apical granules, and finally secreted to the uterine fluid. Results of MMP-26 and TIMP-4 expression i (en)
- Cílem této práce bylo stadium matrix metaloproteinázy-26 (MMP-26) a tkáňového inhibitoru metaloproteináz-4 (TIMP-4) v lidském endometriu. Oba tyto enzymy mohou mít význam pro průběh implantace. Trofoblast jak lidského, tak myšího embrya produkuje pro-MMP-9. Aktivní MMP-9 je proteolytický enzyme s širokou substrátovou specificitou. MMP-26 je účinným aktivátorem pro-MMP-9 a TIMP-4 je silným inhibitorem MMP-26. Prokázali jsme, že endometrální exprese genů MMP-26 a TIMP-4 má maximum uprostřed cyklu. Vzorec exprese obou genů předpokládá jejich up-regulaci estrogenem a down-regulaci progesteronem. Toto je podpořeno naším nálezem estrogen response elementu v kódovací sekvenci obou genů. Naše výsledky předpokládají, že TIMP-4 je produkováno pouze ve stromatu, secernováno stromálními buňkami, vychytáváno epiteliálními buňkami, akumulováno v apikálních granulích a následně secernováno do děložní tekutiny. Výsledky exprese MMP-26 a TIMP-4 v hyperplastickém endometriu jsou v souladu s extrogenem zprostředkovanou (cs)
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| Title
| - MMP-26 and TIMP-4 in the human endometrium
- MMP-26 a TIMP-4 v lidském endometriu (cs)
- MMP-26 and TIMP-4 in the human endometrium (en)
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| skos:prefLabel
| - MMP-26 and TIMP-4 in the human endometrium
- MMP-26 a TIMP-4 v lidském endometriu (cs)
- MMP-26 and TIMP-4 in the human endometrium (en)
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| skos:notation
| - RIV/61989592:15110/08:00007346!RIV09-MSM-15110___
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/61989592:15110/08:00007346
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - human endometrium; MMP-26; TIMP-4; implantation (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/mistoVydani
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| http://linked.open...i/riv/nazevZdroje
| - MMP-26 and TIMP-4 in the human endometrium
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...v/pocetStranKnihy
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...UplatneniVysledku
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| http://linked.open...iv/tvurceVysledku
| - Pilka, Radovan
- Casslén, B.
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| number of pages
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| http://purl.org/ne...btex#hasPublisher
| - Verlag Dr. Müller, Saarbrücken, Germany
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| https://schema.org/isbn
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| http://localhost/t...ganizacniJednotka
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| is http://linked.open...avai/riv/vysledek
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