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| Description
| - Recent study in a group of German patients with SSc has implicated the SNP in the MCP-1 gene (-2518 A to G) as a factor of susceptibility to SSc. Reflecting the need for replication of genetic association studies, we investigated if this SNP is associated with SSc in another Caucasian population. MCP-1 -2518 A/G genotypes were determined using PCR-SSP in 46 SSc patients and in 449 healthy subjects, all unrelated and of Slovak (Slavonic) origin. The distribution of MCP-1 -2518 A/G genotypes complied with the Hardy-Weinberg equilibrium both in patient and healthy control groups. There was no difference in MCP-1 -2518*G allele frequency between SSc patients and healthy subjects (patients: 0.23; controls: 0.24; p>0.05). Furthermore, MCP-1 -2518 GG homozygotes were similarly represented among SSc patients and healthy subjects (p>0.05). The association of MCP-1 -2518 A/G SNP with SSc observed originally in German population was not replicated in the Slovak population.
- Recent study in a group of German patients with SSc has implicated the SNP in the MCP-1 gene (-2518 A to G) as a factor of susceptibility to SSc. Reflecting the need for replication of genetic association studies, we investigated if this SNP is associated with SSc in another Caucasian population. MCP-1 -2518 A/G genotypes were determined using PCR-SSP in 46 SSc patients and in 449 healthy subjects, all unrelated and of Slovak (Slavonic) origin. The distribution of MCP-1 -2518 A/G genotypes complied with the Hardy-Weinberg equilibrium both in patient and healthy control groups. There was no difference in MCP-1 -2518*G allele frequency between SSc patients and healthy subjects (patients: 0.23; controls: 0.24; p>0.05). Furthermore, MCP-1 -2518 GG homozygotes were similarly represented among SSc patients and healthy subjects (p>0.05). The association of MCP-1 -2518 A/G SNP with SSc observed originally in German population was not replicated in the Slovak population. (en)
- Monocyte chemoattractent protein (MCP)-1/CCL2, chemoatraktant pro mononukleární buňky, se významně podílí na imunitní reakci u systémové sklerózy (SS). V německé populaci byla popsána souvislost mezi SS a přítomností alely G na pozici -2518 genu kódujícího MCP-1. Cílem práce bylo zjistit, zda je tato asociace přítomna také ve slovenské populaci. MCP-1 -2518 A/G jednonukleotidový polymorfismus (SNP) byl typizován u 46 pacientů a 449 zdravých kontrolních jedinců pomocí PCR se sekvenčně specifickými primery. Rozdíly v alelické a genotypové frekvenci byly hodnoceny pomocí 2 testu s korekcí dle Woolf-Haldane. Zastoupení MCP-1 -2518 genotypů bylo u našich pacientů a kontrol v Hardy-Weinbergově rovnováze. Alela G se vyskytovala se stejnou frekvencí jak u pacientů tak u zdravých jedinců (pacienti: 0,23; kontrolní skupina: 0,24; p>0,05). Mezi pacienty a kontrolní skupinou nebyly rozdíly ani v četnosti homozygotů (p>0,05). Tato práce nepotvrdila souvislost mezi MCP-1 -2518 SNP A/G a systémovou sklerózou, (cs)
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| Title
| - MCP-1 -2518 A/G single nucleotide polymorphism in Slovak patients with systemic sclerosis.
- MCP-1 -2518 A/G polymorfismus u slovenských pacientů se systémovou sklerózou (cs)
- MCP-1 -2518 A/G single nucleotide polymorphism in Slovak patients with systemic sclerosis. (en)
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| skos:prefLabel
| - MCP-1 -2518 A/G single nucleotide polymorphism in Slovak patients with systemic sclerosis.
- MCP-1 -2518 A/G polymorfismus u slovenských pacientů se systémovou sklerózou (cs)
- MCP-1 -2518 A/G single nucleotide polymorphism in Slovak patients with systemic sclerosis. (en)
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| skos:notation
| - RIV/61989592:15110/08:00007003!RIV09-MSM-15110___
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
| - P(GA310/05/2614), S, Z(MSM6198959205)
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/61989592:15110/08:00007003
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - systemic sclerosis; MCP-1; SNP (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
| - Mediators of Inflammation
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...vavai/riv/projekt
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Kriegová, Eva
- Mrázek, František
- Navrátilová, Zdenka
- Petřek, Martin
- Lukáč, Jozef
- Bucová, Mária
- Bošák, Vladimír
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| http://linked.open...n/vavai/riv/zamer
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| issn
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| number of pages
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| http://localhost/t...ganizacniJednotka
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| is http://linked.open...avai/riv/vysledek
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