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| Description
| - Alkohol je významný rizikový faktor pro vznik karcinomu horní části aerodigestivního traktu a je metabolizován hlavně enzymem alkohol dehydrogenáza (ADH). Ve třech samostatných studiích jsme prozkoumali 6 genetických variant ADH u 3 800 případů karcinomu aerodigestivního traktu a 5 200 kontrol. Genové varianty rs1229984 (ADH1B) a rs1573496 (ADH7) byly protektivní proti rakovině aerodigestivního traktu v každé ze samostatných studií i celkově (P = 10-10, respektive 10-9). Tento efekt byl více zřetelný s rostoucí konzumací alkoholu (P pro trend = 0,0002, respektive 0,065). Oba genové efekty byly na sobě nezávislé, naznačující, že mnohočetné ADH geny mohou být postiženy u karcinomů horního aerodigestivního traktu. (cs)
- Alcohol is an important risk factor for upper aerodigestive cancers and is principally metabolized by alcohol dehydrogenase (ADH) enzymes. We have investigated six ADH genetic variants in over 3,800 aerodigestive cancer cases and 5,200 controls from three individual studies. Gene variants rs1229984 (ADH1B) and rs1573496 (ADH7) were significantly protective against aerodigestive cancer in each individual study and overall (P = 10(-10) and 10(-9), respectively). These effects became more apparent with increasing alcohol consumption (P for trend = 0.0002 and 0.065, respectively). Both gene effects were independent of each other, implying that multiple ADH genes may be involved in upper aerodigestive cancer etiology.
- Alcohol is an important risk factor for upper aerodigestive cancers and is principally metabolized by alcohol dehydrogenase (ADH) enzymes. We have investigated six ADH genetic variants in over 3,800 aerodigestive cancer cases and 5,200 controls from three individual studies. Gene variants rs1229984 (ADH1B) and rs1573496 (ADH7) were significantly protective against aerodigestive cancer in each individual study and overall (P = 10(-10) and 10(-9), respectively). These effects became more apparent with increasing alcohol consumption (P for trend = 0.0002 and 0.065, respectively). Both gene effects were independent of each other, implying that multiple ADH genes may be involved in upper aerodigestive cancer etiology. (en)
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| Title
| - Multiple ADH genes are associated with upper aerodigestive cancers
- Multiple ADH genes are associated with upper aerodigestive cancers (en)
- Mnohočetné ADH geny ve vztahu s karcinomy horního aerodigestivního traktu (cs)
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| skos:prefLabel
| - Multiple ADH genes are associated with upper aerodigestive cancers
- Multiple ADH genes are associated with upper aerodigestive cancers (en)
- Mnohočetné ADH geny ve vztahu s karcinomy horního aerodigestivního traktu (cs)
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| skos:notation
| - RIV/61989592:15110/08:00006197!RIV09-MZ0-15110___
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/61989592:15110/08:00006197
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - upper aerodigestive cancer; alcohol dehydregenase gene; alcohol; case control study (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
| - GB - Spojené království Velké Británie a Severního Irska
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...vavai/riv/projekt
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Hashibe, Mia
- Holcátová, Ivana
- Janout, Vladimír
- Kollárová, Helena
- Mates, Dana
- Szeszenia-Dabrowska, Neonilia
- Canova, Cristina
- Kjaerheim, Kristina
- Lagiou, Pagona
- Merletti, Franco
- Simonato, Lorenzo
- Talamini, Renato
- Richiardi, Lorenzo
- Agudo, Antonio
- Barzan, Luigi
- Benhamou, Simone
- Fernandez, Leticia
- Koifman, Sergio
- Matos, Elena
- Menezes, Ana
- Shangina, Oxana
- Bouchardy, Christine
- Lagiou, Areti
- Castellsagué, Xavier
- Curado, Maria Paula
- Dall'Agnol, Marinel Mór
- Eluf-Neto, Jose
- Koifman, Rosalina
- Lence, Juan
- Levi, Jose Eduardo
- Lowry, Ray
- Macfalrane J, Gary
- Macfalrane V, Tatiana
- Mates, Ioan Nicolae
- McKay D., James
- Oliveira, Jose Carlos
- Wünsch-Filho, Victor
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| http://localhost/t...ganizacniJednotka
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| is http://linked.open...avai/riv/vysledek
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