| Attributes | Values |
|---|
| rdf:type
| |
| Description
| - In a multicenter case-control study of renal cell carcinoma (RCC) conducted in central and eastern Europe, we reported a strong inverse association with high vegetable intake and RCC risk. The odds ratio (OR) for high compared to the lowest tertile of vegetable intake was OR 5 0.67; (95% confidence interval (CI): 0.53?0.83; p-trend < 0.001). We hypothesized that variation in key folate metabolism genes may modify this association. Common variation in 5 folate metabolism genes (CBS: Ex9133C [ T (rs234706), Ex13 141C [ T (rs1801181), Ex18 2391 G [ A (rs12613); MTHFR: A222V Ex5179C[T (rs1801133), Ex8262A [ C (rs1801131); MTR: Ex26 20A [ G (rs1805087), MTRR: Ex51136 T [ C (rs161870), and TYMS:IVS22405 C [ T (rs502396), Ex81157 C[T (rs699517), Ex81227 A[G (rs2790)) were analyzed among 1,097 RCC cases and 1,555 controls genotyped in this study. Having at least 1 variant T allele of MTHFR A222V was associated with higher RCC risk compared to those with 2 common (CC) alleles (OR 5 1.44; 95% CI: 1.17?1.77;
- In a multicenter case-control study of renal cell carcinoma (RCC) conducted in central and eastern Europe, we reported a strong inverse association with high vegetable intake and RCC risk. The odds ratio (OR) for high compared to the lowest tertile of vegetable intake was OR 5 0.67; (95% confidence interval (CI): 0.53?0.83; p-trend < 0.001). We hypothesized that variation in key folate metabolism genes may modify this association. Common variation in 5 folate metabolism genes (CBS: Ex9133C [ T (rs234706), Ex13 141C [ T (rs1801181), Ex18 2391 G [ A (rs12613); MTHFR: A222V Ex5179C[T (rs1801133), Ex8262A [ C (rs1801131); MTR: Ex26 20A [ G (rs1805087), MTRR: Ex51136 T [ C (rs161870), and TYMS:IVS22405 C [ T (rs502396), Ex81157 C[T (rs699517), Ex81227 A[G (rs2790)) were analyzed among 1,097 RCC cases and 1,555 controls genotyped in this study. Having at least 1 variant T allele of MTHFR A222V was associated with higher RCC risk compared to those with 2 common (CC) alleles (OR 5 1.44; 95% CI: 1.17?1.77; (en)
- V multicentrické studii případů a kontrol karcinomu z ledvinných buněk (RCC) provedené ve střední a východní Evropě, byla ohlášena silná inverzní asociace mezi vysokou konzumací zeleniny a RCC rizikem. Odds ratio (OR) pro vysoký tercil v porovnání s nejnižším tercilem příjmu zeleniny bylo OR = 0.67; (95% interval spolehlivosti (IS): 0.53-0.83; p-trend < 0.001). Předpokládali jsme, že variace klíčových genů pro metabolismus folátů může tuto asociaci modifikovat. Běžné variace v 5 genech metabolismu folátů (CBS: Ex9+33C > T (rs234706), Ex13 +41C > T (rs1801181), Ex18 -391 G > A (rs12613); MTHFR: A222V Ex5+79C > T (rs1801133), Ex8-62A > C (rs1801131); MTR: Ex26 20A > G (rs1805087), MTRR: Ex5+136 T > C (rs161870), a TYMS:IVS2-405 C > T (rs502396), Ex8+157 C > T (rs699517), Ex8+227 A > G (rs2790)) byly analyzovány u 1,097 případů RCC a 1,555 kontrolních genotypů v této studii. Přítomnost nejméně jedné varianty T alely MTHFR A222V byla spojena s vyšším rizikem RCC v porovnán (cs)
|
| Title
| - Folate metabolism genes, vegetable intake and renal cancer risk in central Europe
- Geny metabolismu folátů, konzumace zeleniny a karcinom ledvin ve střední Evropě. (cs)
- Folate metabolism genes, vegetable intake and renal cancer risk in central Europe (en)
|
| skos:prefLabel
| - Folate metabolism genes, vegetable intake and renal cancer risk in central Europe
- Geny metabolismu folátů, konzumace zeleniny a karcinom ledvin ve střední Evropě. (cs)
- Folate metabolism genes, vegetable intake and renal cancer risk in central Europe (en)
|
| skos:notation
| - RIV/61989592:15110/08:00006196!RIV09-MZ0-15110___
|
| http://linked.open...avai/riv/aktivita
| |
| http://linked.open...avai/riv/aktivity
| |
| http://linked.open...iv/cisloPeriodika
| |
| http://linked.open...vai/riv/dodaniDat
| |
| http://linked.open...aciTvurceVysledku
| |
| http://linked.open.../riv/druhVysledku
| |
| http://linked.open...iv/duvernostUdaju
| |
| http://linked.open...titaPredkladatele
| |
| http://linked.open...dnocenehoVysledku
| |
| http://linked.open...ai/riv/idVysledku
| - RIV/61989592:15110/08:00006196
|
| http://linked.open...riv/jazykVysledku
| |
| http://linked.open.../riv/klicovaSlova
| - kidney cancer; folate metabolism; 1-C metabolism; TYMS; MTHFR; genetic susceptibility; diet; vegetable intake (en)
|
| http://linked.open.../riv/klicoveSlovo
| |
| http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
|
| http://linked.open...ontrolniKodProRIV
| |
| http://linked.open...i/riv/nazevZdroje
| - International Journal of Cancer (print)
|
| http://linked.open...in/vavai/riv/obor
| |
| http://linked.open...ichTvurcuVysledku
| |
| http://linked.open...cetTvurcuVysledku
| |
| http://linked.open...vavai/riv/projekt
| |
| http://linked.open...UplatneniVysledku
| |
| http://linked.open...v/svazekPeriodika
| |
| http://linked.open...iv/tvurceVysledku
| - Janout, Vladimír
- Kollárová, Helena
- Boffetta, Paolo
- Karami, Sara
- Zaridze, David
- Moore E., Lee
- Berndt, Sonya
- Hsu C., Charles
- Hung, Rayjean
|
| issn
| |
| number of pages
| |
| http://localhost/t...ganizacniJednotka
| |
| is http://linked.open...avai/riv/vysledek
of | |
![[RDF Data]](/fct/images/sw-rdf-blue.png)
![[cxml]](/fct/images/cxml_doc.png)
![[csv]](/fct/images/csv_doc.png)
![[text]](/fct/images/ntriples_doc.png)
![[turtle]](/fct/images/n3turtle_doc.png)
![[ld+json]](/fct/images/jsonld_doc.png)
![[rdf+json]](/fct/images/json_doc.png)
![[rdf+xml]](/fct/images/xml_doc.png)
![[atom+xml]](/fct/images/atom_doc.png)
![[html]](/fct/images/html_doc.png)