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| Description
| - Úvod: Cílem studie bylo stanovit endoteliální hemostatické markery - von Willebrand factor (vWF), plasminogen activator inhibitor-1 (PAI-1), tissue plasminogen activator (t-PA), soluble thrombomodulin (sTM) u asymptomatických jedinců z rodin s familiární kombinovanou hyperlipidémií (FKH). Zjišťovali jsme vztah těchto markerů k tloušťce intima-media společné karotidy (IMT), k vybraným rizikovým faktorům aterosklerózy a k markerům inzulínové rezistence. Metodika: Do prezentované studie bylo zařazeno 82 osob z 29-ti FKH rodin. Soubor byl rozdělen na hyperlipidemické jedince (HL, n=47) a normolipidemické jedince (NL, n=35). Ke skupině HL, resp. NL byla věkově a pohlavím adjustována kontrolní skupina K-HL (n=20), resp. K-NL (n=20). IMT byla měřena ultrazvukem na vzdálené stěně obou společných karotid. Výsledky: Ve srovnání se zdravými kontrolami, měli hyperlipidemičtí jedinci signifikantně vyšší hladiny vWF (146.4?73.2 % versus 112.2?29.4 %, p<0.05 ), PAI-1 (102.4[83.0-117.0] ng/ml versus 63.5[31.8 (cs)
- Introduction: The aim of this study was to evaluate the plasma levels of endothelial haemostatic markers - von Willebrand factor (sWF), plasminogen activator inhibitor-1 (PAI-1), tissue plasminogen activator (t-PA) and soluble thrombomodulin (sTM) - in asymptomatic, nonsmoking members of families with familial combined hyperlipidemia (FCH). We investigated the association between these factors and the intima-media thickness (IMT) of the common carotid artery, selected risk factors of atherosclerosis and markers of insulin resistance. Methods. 82 members of 29 FCH families were divided into two groups: HL (probands and hyperlipidemic first - degree relatives, n=47) and NL (normolipidemic first-degree relatives, n=35). The control groups C-HL (n=20) and C-NL (n=20) consisted of sex- and age-matched healthy individuals. IMT was measured by ultrasound at a far wall of both common carotid arteries. Results: Compared with healthy controls, hyperlipidemic subjects had significantly higher levels of vWF (
- Introduction: The aim of this study was to evaluate the plasma levels of endothelial haemostatic markers - von Willebrand factor (sWF), plasminogen activator inhibitor-1 (PAI-1), tissue plasminogen activator (t-PA) and soluble thrombomodulin (sTM) - in asymptomatic, nonsmoking members of families with familial combined hyperlipidemia (FCH). We investigated the association between these factors and the intima-media thickness (IMT) of the common carotid artery, selected risk factors of atherosclerosis and markers of insulin resistance. Methods. 82 members of 29 FCH families were divided into two groups: HL (probands and hyperlipidemic first - degree relatives, n=47) and NL (normolipidemic first-degree relatives, n=35). The control groups C-HL (n=20) and C-NL (n=20) consisted of sex- and age-matched healthy individuals. IMT was measured by ultrasound at a far wall of both common carotid arteries. Results: Compared with healthy controls, hyperlipidemic subjects had significantly higher levels of vWF ( (en)
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| Title
| - Endothelial haemostatic markers in members of families with familial combined hyperlipidemia
- Endothelial haemostatic markers in members of families with familial combined hyperlipidemia (en)
- Endoteliální hemostatické markery u jedinců z rodin s familiární kombinovanou hyperlipidemií (cs)
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| skos:prefLabel
| - Endothelial haemostatic markers in members of families with familial combined hyperlipidemia
- Endothelial haemostatic markers in members of families with familial combined hyperlipidemia (en)
- Endoteliální hemostatické markery u jedinců z rodin s familiární kombinovanou hyperlipidemií (cs)
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| skos:notation
| - RIV/61989592:15110/08:00006144!RIV09-MZ0-15110___
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/61989592:15110/08:00006144
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - von Willebrand factor; plasminogen activator inhibitor-1; tissue plasminogen activator; soluble thrombomodulin; familial combined hyperlipidemia; intima-media thickness (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...vavai/riv/projekt
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Slavík, Luděk
- Vaverková, Helena
- Halenka, Milan
- Karásek, David
- Novotný, Dalibor
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| http://localhost/t...ganizacniJednotka
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