| Attributes | Values |
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| rdf:type
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| Description
| - Idiopatická plicní fibróza (IPF) je těžké plicní onemocnění neznámé etiologie s významnou genetickou složkou. Jednonukleotidový polymorfismus (SNP) C5507G genu pro komplementový receptor 1, ovlivňující počet CR1 molekul na erytrocytech, byl asociován s vnímavostí k IPF u evropské populace. Za účelem replikace těchto závěrů bylo vyšetřeno 53 českých IPF pacientů s 203 českými kontrolami a 70 anglických IPF Pacientů se 149 anglickými kontrolami. V žádné z populací nebyly nalezeny signifikantní rozdíly v distribuci CR1 C5507G variant mezi IPF pacienty a příslušnými kontrolními skupinami. Závěrem lze tedy říci, že asociace CR1 C5507G polymorfismu a vnímavosti k IPF nebyla u české a anglické populace potvrzena. (cs)
- Idiopathic pulmonary fibrosis (IPF), a severe lung disease with unknown aetiology, is thought to have an important genetic component. Single nucleotide polymorphism (SNP), C5507G, of the CR1 gene, which affects the number of CR1 molecules on erythrocytes, has been associated with susceptibility to IPF in a single European population. In order to replicate this finding, 53 Czech IPF patients with 203 Czech healthy control subjects and 70 English IPF patients with 149 English controls were investigated. In both populations, there were no significant differences in distribution of CR1 C5507G variants between IPF patients and thein appropriate control groups. In conclusion, the association of the CR1 C5507G polymorphism with susceptibility to IPF was not reproducible in Czech and English populations.
- Idiopathic pulmonary fibrosis (IPF), a severe lung disease with unknown aetiology, is thought to have an important genetic component. Single nucleotide polymorphism (SNP), C5507G, of the CR1 gene, which affects the number of CR1 molecules on erythrocytes, has been associated with susceptibility to IPF in a single European population. In order to replicate this finding, 53 Czech IPF patients with 203 Czech healthy control subjects and 70 English IPF patients with 149 English controls were investigated. In both populations, there were no significant differences in distribution of CR1 C5507G variants between IPF patients and thein appropriate control groups. In conclusion, the association of the CR1 C5507G polymorphism with susceptibility to IPF was not reproducible in Czech and English populations. (en)
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| Title
| - The CR1 C5507G polymorphism is not involved in susceptibility to IPF in two European populations
- The CR1 C5507G polymorphism is not involved in susceptibility to IPF in two European populations (en)
- CR1 C5507G polymorfismus nesouvisí s vnímavostí k IPF ve dvou evropských populacích (cs)
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| skos:prefLabel
| - The CR1 C5507G polymorphism is not involved in susceptibility to IPF in two European populations
- The CR1 C5507G polymorphism is not involved in susceptibility to IPF in two European populations (en)
- CR1 C5507G polymorfismus nesouvisí s vnímavostí k IPF ve dvou evropských populacích (cs)
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| skos:notation
| - RIV/61989592:15110/08:00006076!RIV09-MZ0-15110___
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
| - P(NR9037), S, Z(MSM6198959205)
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/61989592:15110/08:00006076
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - Case-control study; complement receptor 1; European population; gene polymorphism; genetics of complex diseases; idiopathic pulmonary fibrosis (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...vavai/riv/projekt
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Arakelyan, Arsen
- Kriegová, Eva
- Mrázek, František
- Petřek, Martin
- du Bois, Roland M.
- Zatloukal, Jaromír
- Kolek, Vitězslav
- Hutyrová, Beáta
- Kubištová, Zuzana
- Lagan, Anna L.
- Lympany, Penny A.
- Welsh, Kenneth I.
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| http://linked.open...n/vavai/riv/zamer
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| issn
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| number of pages
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| http://localhost/t...ganizacniJednotka
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| is http://linked.open...avai/riv/vysledek
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