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Description
  • Kandidóza, infekce způsobená pučícími formami houby kandida představuje heterogenní skupinu onemocnění od systémové, přes mukokutánní až po vvulvovaginální formu. Přestože všechny formy jsou způsobeny stejným organismem, každá je kontrolována odlišnými mechanismy hostitelské obrany. Fagocytóza zprostředkována polymorfonukleáry a makrofágy je obecně přijímaná jako hlavní mechanismus eliminace kandidy z organismu. Fagocyty vyžzdují stimulaci proinflamatorními cytokiny což může být nebezpečné pro organismus a musí být regulováno aktivitou CD8 a CD4 T lymfocytů. Na sliznici vagíny jsou fagocyty neefektivní a lokální zánět je obecně nechtěnná reakce neboť se může podílet na poškození tkáně a poruše tolerance k běžným vaginálním antigenům mezi něž patří i normálně saprofytující kandida. Rekurentní forma vulvovaginální kandidózy je pravděpodobně spojena s porušením takové tolerance. Mimo fagocyty, specifické protilátky, komplement a vaginální epiteliální buňky jsou zapojeny do obrany proti kandidě. Jsou reg (cs)
  • Candidiases, infections caused by germination forms of the Candida fungus, represent a heterogeneous group of diseases from systemic infection, through mucocutaneous form, to vulvovaginal form. Although caused by one organism, each form is controlled by distinct host immune mechanisms. Phagocytosis by polymorphonuclears and macrophages is generally accepted as the host immune mechanism for Candida elimination. Phagocytes require proinflammatory cytokine stimulation which could be harmful and must be regulated during the course of infection by the activity of CD8+ and CD4+ T cells. In the vaginal tissue the phagocytes are inefficient and inflammation is generally an unwanted reaction because it could damage mucosal tissue and break the tolerance to common vagina antigens including the otherwise saprophyting Candida yeast. Recurrent form of vulvovaginal candidiasis is probably associated with breaking of such tolerance. Beside the phagocytosis, specific antibodies, complement, and mucosal epithelial ce
  • Candidiases, infections caused by germination forms of the Candida fungus, represent a heterogeneous group of diseases from systemic infection, through mucocutaneous form, to vulvovaginal form. Although caused by one organism, each form is controlled by distinct host immune mechanisms. Phagocytosis by polymorphonuclears and macrophages is generally accepted as the host immune mechanism for Candida elimination. Phagocytes require proinflammatory cytokine stimulation which could be harmful and must be regulated during the course of infection by the activity of CD8+ and CD4+ T cells. In the vaginal tissue the phagocytes are inefficient and inflammation is generally an unwanted reaction because it could damage mucosal tissue and break the tolerance to common vagina antigens including the otherwise saprophyting Candida yeast. Recurrent form of vulvovaginal candidiasis is probably associated with breaking of such tolerance. Beside the phagocytosis, specific antibodies, complement, and mucosal epithelial ce (en)
Title
  • Candidiasis ? Do We Need to Fight or to Tolerate the Candida Fungus?
  • Kandidóza. je třeba bojovat s nebo tolerovat houbu kandida (cs)
  • Candidiasis ? Do We Need to Fight or to Tolerate the Candida Fungus? (en)
skos:prefLabel
  • Candidiasis ? Do We Need to Fight or to Tolerate the Candida Fungus?
  • Kandidóza. je třeba bojovat s nebo tolerovat houbu kandida (cs)
  • Candidiasis ? Do We Need to Fight or to Tolerate the Candida Fungus? (en)
skos:notation
  • RIV/61989592:15110/07:00004337!RIV08-MSM-15110___
http://linked.open.../vavai/riv/strany
  • 297-312
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(ME 875), Z(MSM6198959223)
http://linked.open...iv/cisloPeriodika
  • 3
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 412581
http://linked.open...ai/riv/idVysledku
  • RIV/61989592:15110/07:00004337
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • Candidiasis; vaginal candidiasis; tolerance; antibody (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • CZ - Česká republika
http://linked.open...ontrolniKodProRIV
  • [EFF210E938FC]
http://linked.open...i/riv/nazevZdroje
  • Folia Microbiologica
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 52
http://linked.open...iv/tvurceVysledku
  • Raška, Milan
  • Weigl, Evžen
  • Křupka, Michal
  • Běláková, Jana
http://linked.open...n/vavai/riv/zamer
issn
  • 0015-5632
number of pages
http://localhost/t...ganizacniJednotka
  • 15110
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