| Attributes | Values |
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| rdf:type
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| Description
| - SLE je onemocnění charakterizované nadprodukcí různých typů autoprotilátek. Za jistých okolností lze zjistit přítomnost autoprotilátek rovněž proti neoepitopům komplementového systému. Neoepitopy nejsou přítomny v nativních proteinech, ale objevují se při jejich strukturálních změnách. Mezi známé antikomplementové autoprotilátky patří: C3 nefritický faktor, protilátka proti C1 inhibitoru či protilátky proti C1R (C1 receptor). Bezesporu nejvýznamnější autoprotilátkou proti komplementu jsou anti-C1q protilátky. Jsou přítomny asi u třetiny nemocných se SLE, korelují s klinickou aktivitou a s přítomností lupusové glomerulonefritidy. Vysoké titry anti C1q protilátek jsou doprovázeny sníženými hladinami C1 ale také C3 a zejména C4 složky komplementu. Přítomnost anti-C1q protilátek není omezena či specifická pouze pro lupus. Poprvé byly popsány v případě syndromu HUVS (Hypocomplementemic Urticar Vasculitis Sydrome), později také při Feltyho syndromu, revmatoidní vaskulitidě, u hepatitidy C a ve stárnoucí (cs)
- Systemic lupus erythematosus (SLE) is an autoimmune disorder which affects multiple organ systems and whose etiology still remains unknown. Nonetheless, many aspects of cellular and molecular interaction leading to the loss of self-tolerance have been clarified. The complement system plays a major yet ambivalent role in pathogenesis of systemic diseases especially SLE. On the one hand activation of the complement system leads to organ damage; on the other hand the complement system partakes in preserving the solubility of immune complexes and their transport to phagocytes of the reticulum-endothelial system and on the clearance of apoptotic cells from circulation. Both hereditary and acquired complement deficiencies are linked to various diseases. SLE can be considered as a prototype of autoimmune disease, and can be used to demonstrate a variety of examples of complement dysfunction. The dysfunctions of the complement system aren?t only epiphenomenon found in SLE; they also play a fundamental role
- Systemic lupus erythematosus (SLE) is an autoimmune disorder which affects multiple organ systems and whose etiology still remains unknown. Nonetheless, many aspects of cellular and molecular interaction leading to the loss of self-tolerance have been clarified. The complement system plays a major yet ambivalent role in pathogenesis of systemic diseases especially SLE. On the one hand activation of the complement system leads to organ damage; on the other hand the complement system partakes in preserving the solubility of immune complexes and their transport to phagocytes of the reticulum-endothelial system and on the clearance of apoptotic cells from circulation. Both hereditary and acquired complement deficiencies are linked to various diseases. SLE can be considered as a prototype of autoimmune disease, and can be used to demonstrate a variety of examples of complement dysfunction. The dysfunctions of the complement system aren?t only epiphenomenon found in SLE; they also play a fundamental role (en)
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| Title
| - Complement: a friend or foe in systemic lupus erythematosus?
- Complement: a friend or foe in systemic lupus erythematosus? (en)
- Komplement: přítel či nepřítel systémového lupus erythematosus? (cs)
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| skos:prefLabel
| - Complement: a friend or foe in systemic lupus erythematosus?
- Complement: a friend or foe in systemic lupus erythematosus? (en)
- Komplement: přítel či nepřítel systémového lupus erythematosus? (cs)
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| skos:notation
| - RIV/61989592:15110/07:00004301!RIV08-MSM-15110___
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| http://linked.open.../vavai/riv/strany
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
| |
| http://linked.open...ai/riv/idVysledku
| - RIV/61989592:15110/07:00004301
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| http://linked.open...riv/jazykVysledku
| |
| http://linked.open.../riv/klicovaSlova
| - systemic lupus erythematosus; complement system; antibodies against complement system (en)
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| http://linked.open.../riv/klicoveSlovo
| |
| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
| - Systemic Lupus Erythematosus Research Developments
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| http://linked.open...in/vavai/riv/obor
| |
| http://linked.open...ichTvurcuVysledku
| |
| http://linked.open...cetTvurcuVysledku
| |
| http://linked.open...UplatneniVysledku
| |
| http://linked.open...iv/tvurceVysledku
| - Ciferská, Hana
- Heřmanová, Zuzana
- Horák, Pavel
- Tichý, Tomáš
- Zadražil, Josef
- Ordeltová, Marta
|
| number of pages
| |
| http://purl.org/ne...btex#hasPublisher
| - Nova Science Publishers, Inc.
|
| https://schema.org/isbn
| |
| http://localhost/t...ganizacniJednotka
| |
| is http://linked.open...avai/riv/vysledek
of | |
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