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| Description
| - Huntingtonova nemoc (HN) je důsledek geneticky programované degenerace mozkových buněk, které nazýváme neurony. Tato degenerace způsobuje nekontrolovatelné pohyby, ztrátu kognitivních schopností a emoční poruchy. HN je dědičná choroba, přenášena z rodičů na děti pomoci mutace v normálním genu. Každé dítě s rodiči trpící HN má pravděpodobnost 50-50 zdědit HN gen. Některé časné symptomy HN se projevují prudkou změnou nálady, depresemi, podrážděností nebo problémy s řízením auta, učením nových věcí, pamatovaním si nebo rozhodovaním. Jakmile se nemoc rozvine, stává se otázka koncentrace a intelektu stále složitější, pacient mívá problémy s příjmem stravy a polykáním (dysfagie). Rychlost rozvoje choroby a věk v době jejího začátku je u každého člověka odlišný. Genetický test spolu s kompletní lékařskou anamnézou, neurologickými a laboratorními testy, pomáhají lekaři diagnostikovat HN. Presymptomatické testování je k dispozici pro osoby, které jsou v rizikové skupině pro přenos HN genu. U 1- 3 % o (cs)
- Background: Steroid hormone receptors constitute a special group of receptors having a wide range of efficiency and distribution in the body. Androgen and estrogen receptors, and their expression in the body, are linked with attributes such as reproduction control and sexual behaviour, but their relation with behavioural models, perception, memory and stress remain unclear to date. Purpose: In this project we aim to focus on monitoring the expressive influence of steroid hormone receptors on embryonic tissues and subsequently, expand our study to include the expression on adult tissues such as the CNS and to monitor the developmental aspects and relations pertaining to neurodegenerative disorders, such as Huntington?s disease. Material and Methods: We shall rely on immuno-histochemistry, immuno-fluorescence and RT-PCR methods for detecting steroid hormone receptors and Huntingtin-associated protein 1 in the embryonic and adult tissue. Conclusion: mapping the expression of steroid receptors during deve
- Background: Steroid hormone receptors constitute a special group of receptors having a wide range of efficiency and distribution in the body. Androgen and estrogen receptors, and their expression in the body, are linked with attributes such as reproduction control and sexual behaviour, but their relation with behavioural models, perception, memory and stress remain unclear to date. Purpose: In this project we aim to focus on monitoring the expressive influence of steroid hormone receptors on embryonic tissues and subsequently, expand our study to include the expression on adult tissues such as the CNS and to monitor the developmental aspects and relations pertaining to neurodegenerative disorders, such as Huntington?s disease. Material and Methods: We shall rely on immuno-histochemistry, immuno-fluorescence and RT-PCR methods for detecting steroid hormone receptors and Huntingtin-associated protein 1 in the embryonic and adult tissue. Conclusion: mapping the expression of steroid receptors during deve (en)
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| Title
| - HUNTINGTON´S DISEASE AND STEROID HORMONE RECEPTORS
- Huntingtonova choroba a steroidní receptory (cs)
- HUNTINGTON´S DISEASE AND STEROID HORMONE RECEPTORS (en)
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| skos:prefLabel
| - HUNTINGTON´S DISEASE AND STEROID HORMONE RECEPTORS
- Huntingtonova choroba a steroidní receptory (cs)
- HUNTINGTON´S DISEASE AND STEROID HORMONE RECEPTORS (en)
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| skos:notation
| - RIV/61989592:15110/07:00004219!RIV08-MSM-15110___
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| http://linked.open.../vavai/riv/strany
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/61989592:15110/07:00004219
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - Huntington?s disease (HD); steroid hormone receptors (SHR); clinical picture (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Molíková, Radka
- Bezdičková, Marcela
- Bébarová, Linda
- David, Ondřej
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| issn
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| number of pages
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| http://localhost/t...ganizacniJednotka
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| is http://linked.open...avai/riv/vysledek
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