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| Description
| - The objective of the present 15-day study was to evaluate the cardioprotective potential of flavonoid pomiferin isolated from the infructences of Maclura pomifera, Moraceae, against ischemia-reperfusion induced injury in rat hearts as a model of antioxidant-based composite therapy. Studies were perfomed with isolated modified Langendorff-perfused rat hearts and ischemia of heart was initiated by stopping the coronary flow for 30 min, followed by 60 min of reperfusion (14 ml-min). Wistar rats were divided into three groups. The treated group received pomiferin (5 mg/kg/day in 5% Avicel); the placebo group received only 5% Avicel; the intact group was left without any applications. Biochemical indicators of oxidative damage, lipid peroxidation product malondialdehyde, antioxidant enzymes (superoxide dismutase, glutathione peroxidase, total antioxidant activity in serum and myocardium has been evaluated.
- The objective of the present 15-day study was to evaluate the cardioprotective potential of flavonoid pomiferin isolated from the infructences of Maclura pomifera, Moraceae, against ischemia-reperfusion induced injury in rat hearts as a model of antioxidant-based composite therapy. Studies were perfomed with isolated modified Langendorff-perfused rat hearts and ischemia of heart was initiated by stopping the coronary flow for 30 min, followed by 60 min of reperfusion (14 ml-min). Wistar rats were divided into three groups. The treated group received pomiferin (5 mg/kg/day in 5% Avicel); the placebo group received only 5% Avicel; the intact group was left without any applications. Biochemical indicators of oxidative damage, lipid peroxidation product malondialdehyde, antioxidant enzymes (superoxide dismutase, glutathione peroxidase, total antioxidant activity in serum and myocardium has been evaluated. (en)
- Studie se zabývá kardioprotektivním potenciálem flavonoidu pomiferinu, izolovaného z plodů Maclura pomifera, Moraceae, na modelu izolovaného perfundovaného myokardu v podmínkách ischemicko-reperfuzního poškození. Studie byla provedena na izolovaných srdcích laboratorního potkana, které byly perfundovány modifikovanou metodou dle Langendorffa. Po stabilizační, 10 minutové fázi (koronární perfuze 14 ml-min) byla navozena ischémie srdce zástavou perfuze na dobu 30 minut, poté následovala reperfuze na dobu 60 minut (průtok 14 ml-min). (cs)
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| Title
| - Protective Effects of Flavonoid Pomiferin on Heart Ischemia-Reperfusion
- Protektivní vliv flavonoidu pomiferinu na ischemii-reperfuzi srdce (cs)
- Protective Effects of Flavonoid Pomiferin on Heart Ischemia-Reperfusion (en)
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| skos:prefLabel
| - Protective Effects of Flavonoid Pomiferin on Heart Ischemia-Reperfusion
- Protektivní vliv flavonoidu pomiferinu na ischemii-reperfuzi srdce (cs)
- Protective Effects of Flavonoid Pomiferin on Heart Ischemia-Reperfusion (en)
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| skos:notation
| - RIV/61989592:15110/07:00004178!RIV08-MSM-15110___
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| http://linked.open.../vavai/riv/strany
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/61989592:15110/07:00004178
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - Maclura pomifera; pomiferin; cardioprotection; superoxide dismutase; glutathione peroxidase; total antioxidative capacity; cardiac function (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Bartošík, Tomáš
- Nečas, Jiří
- Suchý, V.
- Bartošíková, Lenka
- Klusáková, J.
- Florian, T.
- El Naggar, E. M. B.
- Janoštíková, E.
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| http://localhost/t...ganizacniJednotka
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| is http://linked.open...avai/riv/vysledek
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