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| Description
| - Previous clinical data suggested that with a tacrolimus-based regimen adjunctive immunosuppressives may be withdrawn after an initial treatment period. This study investigated the early discontinuation of mycophenolate mofetil (MMF) from a standard triple regimen. Patients were randomized either to receive a continued tacrolimus /MMF/ steroids triple regimen (control group) or to reduce and then stop the MMF dose (MMF stop group). Both groups received identical daily tacrolimus and corticosteroid doses. The initial MMF dose was l g/day in both arms, but in the MMF stop group the dose was reduced to 0,5 g/day from week 7 to 12 and then stopped. The intent-to-treat population consisted of 74 (control) and 78 (MMF stop) patients. MMF was tapered off as planned in 82.9% of the patients in the MMF stop arm. The 6-month incidence of biopsy-proven acute rejection was similar in both arms (21.6% control, 16.7% MMMF stop). Graft loss occurred in 5.4% (control) and 3.8% (MMF stop) of the patients. MMF could be
- Previous clinical data suggested that with a tacrolimus-based regimen adjunctive immunosuppressives may be withdrawn after an initial treatment period. This study investigated the early discontinuation of mycophenolate mofetil (MMF) from a standard triple regimen. Patients were randomized either to receive a continued tacrolimus /MMF/ steroids triple regimen (control group) or to reduce and then stop the MMF dose (MMF stop group). Both groups received identical daily tacrolimus and corticosteroid doses. The initial MMF dose was l g/day in both arms, but in the MMF stop group the dose was reduced to 0,5 g/day from week 7 to 12 and then stopped. The intent-to-treat population consisted of 74 (control) and 78 (MMF stop) patients. MMF was tapered off as planned in 82.9% of the patients in the MMF stop arm. The 6-month incidence of biopsy-proven acute rejection was similar in both arms (21.6% control, 16.7% MMMF stop). Graft loss occurred in 5.4% (control) and 3.8% (MMF stop) of the patients. MMF could be (en)
- Předchozí klinická data naznačovala, že v imunosupresivné terapii, která je postavena na tacrolimu, lze po počátečním léčebném období podpůrnou terapii odstranit. Tato studie hodnotí časné vysazení mykofenolát mofetilu (MMF) ze standardní imunosupresivní trojkombinace (standard triple regiment). Nemocní byli randomizováni do dvou skupin, v první dostávali kontinuálně trojkombinaci tacrolimus /MMF/ steroidy (kontrolní skupina), ve druhé skupině byl MMF redukován a následně byl MMF vysazen (MMF stop group). Obě skupiny dostávali shodně denní dávky tacrolimu a kortikoidů. Počáteční dávka MMF byla v obou odvětvích 1g denně, ve skupině, kde byl MMF později vysazen byla dávka redukována na 0,5 g denně od 7 do 12 týdně a potom byl MMF vysazen. Sledované skupiny tvořilo 74 (kontrolní skupina) a 78 (MMF stop) nemocných. Skupina s MMF se zúžila z plánovaného počtu 82,9 % nemocných ve skupině MMF stop. V obou skupinách byla prokázána podobná 6 měsíční incidenc e biopticky ověřených akutních rejekcí (21,6% u kont (cs)
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| Title
| - Discontinuation of mycophenolate mofetil from a tacrolimus-based triple 2 months after renal transplantation : a comparative randomized multicentre study
- Vysazení mykofenolát mofetilu z imunosupresivního protokolu založeném na trojkombinaci s tacrolimem 2 měsíce po transplantaci ledvin: srovnávací randomizovaná multicentrická studie. (cs)
- Discontinuation of mycophenolate mofetil from a tacrolimus-based triple 2 months after renal transplantation : a comparative randomized multicentre study (en)
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| skos:prefLabel
| - Discontinuation of mycophenolate mofetil from a tacrolimus-based triple 2 months after renal transplantation : a comparative randomized multicentre study
- Vysazení mykofenolát mofetilu z imunosupresivního protokolu založeném na trojkombinaci s tacrolimem 2 měsíce po transplantaci ledvin: srovnávací randomizovaná multicentrická studie. (cs)
- Discontinuation of mycophenolate mofetil from a tacrolimus-based triple 2 months after renal transplantation : a comparative randomized multicentre study (en)
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| skos:notation
| - RIV/61989592:15110/07:00004033!RIV08-MSM-15110___
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| http://linked.open.../vavai/riv/strany
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/61989592:15110/07:00004033
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - immunosuppression; mycophenolate mofetil; renal transplantation; tacrolimus (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
| - GB - Spojené království Velké Británie a Severního Irska
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Navrátil, Pavel
- Lacková, Eva
- Samlík, Jiří
- Bachleda, Petr
- Rutkowski, Boleslaw
- Studeník, Pavel
- Mysliwiec, Michal
- Sulowicz, Wladyslaw
- Gumprecht, Janusz
- Asztalos, Lászlo
- Hruby, Zbigniew
- Ksiazek, Andrzej
- Rydzewski, Andrzej
- Szakály, Péter
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| number of pages
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| http://localhost/t...ganizacniJednotka
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| is http://linked.open...avai/riv/vysledek
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