About: Molecular dissection of t)11;17) in acute myeloid leukemia reveals a variety of gene fusions with heterogeneous fusion transcripts and multiple splice variants     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
Description
  • The majority of translocations that involve the long arms of chromosomes 11 and 17 in acute myeloid leukemia appear identical on the cytogenetic level. nevertheless, they are diverse on the molecular level. At present, two genes are known in 11q23 and four in 17q12-25 that generate five distinct fusion genes: MLL-MLLT6/AF17, MLL- LASP1, MLL-ACACA or MLL-SEPT9/MSF, and ZBTB16/PLZF-RARA. We analyzed 14 cases with a t (11;17) by fluorescence in situ hybridization and molecular genetic techniques and determined the molecular characteristics of their fusion genes. We identified six different gene fusions that comprised seven cases eith a MLL-MLLT6/AF17, three with a MLL-SEPT9/MSF and one each with MLL-LASP1, MLL-ACACA and ZBTB16/PLZF-RARA fusions. In the remaining case, a MLL-SEPT6/Xq24 fusion suggested a complex rearrangement. The MLL-MLL6/AF17 transcripts were extremely heterogeneous and the detection of seven different in-frame transcript and splice variants enabled us to predict the protein domain rele
  • The majority of translocations that involve the long arms of chromosomes 11 and 17 in acute myeloid leukemia appear identical on the cytogenetic level. nevertheless, they are diverse on the molecular level. At present, two genes are known in 11q23 and four in 17q12-25 that generate five distinct fusion genes: MLL-MLLT6/AF17, MLL- LASP1, MLL-ACACA or MLL-SEPT9/MSF, and ZBTB16/PLZF-RARA. We analyzed 14 cases with a t (11;17) by fluorescence in situ hybridization and molecular genetic techniques and determined the molecular characteristics of their fusion genes. We identified six different gene fusions that comprised seven cases eith a MLL-MLLT6/AF17, three with a MLL-SEPT9/MSF and one each with MLL-LASP1, MLL-ACACA and ZBTB16/PLZF-RARA fusions. In the remaining case, a MLL-SEPT6/Xq24 fusion suggested a complex rearrangement. The MLL-MLL6/AF17 transcripts were extremely heterogeneous and the detection of seven different in-frame transcript and splice variants enabled us to predict the protein domain rele (en)
  • Většina translokací postihujících u nemocných s akutní myeloidní leukemií dlouhá raménka chromosomů 11 a 17 má při cytogenetickém vyšetření identický obraz. Na molekulární úrovni jde o různé fúzní geny. V práci jsou popisovány molekulární charakteristiky leukemických fúzí u 14 případů AML s t(11;17). (cs)
Title
  • Molecular dissection of t)11;17) in acute myeloid leukemia reveals a variety of gene fusions with heterogeneous fusion transcripts and multiple splice variants
  • Molekulární analýza translokace t(11;17) u akutní myeloidní leukemie odhaluje přítomnost různých genových fúzí s heterogenní transkripcí a četnými variantami (cs)
  • Molecular dissection of t)11;17) in acute myeloid leukemia reveals a variety of gene fusions with heterogeneous fusion transcripts and multiple splice variants (en)
skos:prefLabel
  • Molecular dissection of t)11;17) in acute myeloid leukemia reveals a variety of gene fusions with heterogeneous fusion transcripts and multiple splice variants
  • Molekulární analýza translokace t(11;17) u akutní myeloidní leukemie odhaluje přítomnost různých genových fúzí s heterogenní transkripcí a četnými variantami (cs)
  • Molecular dissection of t)11;17) in acute myeloid leukemia reveals a variety of gene fusions with heterogeneous fusion transcripts and multiple splice variants (en)
skos:notation
  • RIV/61989592:15110/06:00003510!RIV07-MSM-15110___
http://linked.open.../vavai/riv/strany
  • 1041-1049
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • Z(MSM6198959205)
http://linked.open...iv/cisloPeriodika
  • 11
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 486605
http://linked.open...ai/riv/idVysledku
  • RIV/61989592:15110/06:00003510
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • acute monocytic leukemia; acute myelomonocytic leukemia; acute promyelocytic leukemia; acute myeloblastic-leukemia; acute myelocytic-leukemi; septin ffamily gene; adult de-novo; MLL gene; leucine-zipper, retinoic acid (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • US - Spojené státy americké
http://linked.open...ontrolniKodProRIV
  • [1B0E3652C85D]
http://linked.open...i/riv/nazevZdroje
  • Genes, Chromosomes and Cancer
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 45
http://linked.open...iv/tvurceVysledku
  • Jarošová, Marie
  • Jäger, U.
  • Meyer, C.
  • Schmidt, H.
  • Harbott, J.
  • Strehl, S.
  • Schneider, B.
  • Haas, O.
  • Moore, S.
  • Marschalek, Rolf
  • Konig, M.
  • Von bergh, A.
http://linked.open...n/vavai/riv/zamer
issn
  • 1045-2257
number of pages
http://localhost/t...ganizacniJednotka
  • 15110
is http://linked.open...avai/riv/vysledek of
Faceted Search & Find service v1.16.118 as of Jun 21 2024


Alternative Linked Data Documents: ODE     Content Formats:   [cxml] [csv]     RDF   [text] [turtle] [ld+json] [rdf+json] [rdf+xml]     ODATA   [atom+xml] [odata+json]     Microdata   [microdata+json] [html]    About   
This material is Open Knowledge   W3C Semantic Web Technology [RDF Data] Valid XHTML + RDFa
OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 112 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software