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Description
  • Receptory, které podléhají translokaci mezi buněčným jádrem a cytosolem, vyžadují pro svou fyziologickou funkci mikrotubuly. Je to tedy rozpad mikrotubulární sítě nebo jednoduše zástava buněčného cyklu v G2/M fázi, jež jsou odpovědné za změnu aktivity těchto receptorů? Podmínky interakce s mikrotubuly a integrita versus dynamika mikrotubulů jsou faktory, které ovlivňují design ideálního léčiva. (cs)
  • Receptors that undergo nucleo-cytoplasmic shuttling require microtubules for proper physiologic function. Is it the collapse of microtubules network or simply the arrest of cell cycle in G2/M phase that changes receptors function? The terms od disengagement and the integrity versus dynamics of the microtubules shall guide the ideal drug design.
  • Receptors that undergo nucleo-cytoplasmic shuttling require microtubules for proper physiologic function. Is it the collapse of microtubules network or simply the arrest of cell cycle in G2/M phase that changes receptors function? The terms od disengagement and the integrity versus dynamics of the microtubules shall guide the ideal drug design. (en)
Title
  • Microtubules and commuting receptors
  • Microtubules and commuting receptors (en)
  • Mikrotubuly a translokující receptory (cs)
skos:prefLabel
  • Microtubules and commuting receptors
  • Microtubules and commuting receptors (en)
  • Mikrotubuly a translokující receptory (cs)
skos:notation
  • RIV/61989592:15110/06:00003472!RIV07-MSM-15110___
http://linked.open.../vavai/riv/strany
  • 567-568
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • Z(MSM6198959216)
http://linked.open...iv/cisloPeriodika
  • 8
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
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http://linked.open...dnocenehoVysledku
  • 485722
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  • RIV/61989592:15110/06:00003472
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • Cytoskeleton; Trancriptional regulation; Nuclear receptors; Drug metabolism (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • NL - Nizozemsko
http://linked.open...ontrolniKodProRIV
  • [EE65D8C27718]
http://linked.open...i/riv/nazevZdroje
  • Letters in Drug Design & Discovery
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 3
http://linked.open...iv/tvurceVysledku
  • Dvořák, Zdeněk
  • Ulrichová, Jitka
  • Modrianský, Martin
http://linked.open...n/vavai/riv/zamer
issn
  • 1570-1808
number of pages
http://localhost/t...ganizacniJednotka
  • 15110
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