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| Description
| - The subchronic safety of sanguiritrin, a mixture of sanguinarine (SA) and chelerythrine (CHE) quaternary benzo[c]phenanthridine alkaloids (QBA), obtained from Macleaya cordata was assessed. Rats were fed a diet containing 120 ppm sanguiritrin (100 ppm QBA) for 109 days. The feed consumption and the animal weight were monitored. The content of QBA in selected tissues and plasma was determined using HPLC. It was evidenced that 2 % of QBA were absorbed through the GIT while 98 % were excreted in the feces. In plasma, bilirubin, urea, creatinine, glomerular filtration, AST, ALT, GMT, ALP and total antioxidant capacity were determined. In liver, GSH level, lipoperoxidation products, SOD and GPx activities and total amount of cytochrome P450 were evaluated. Damage to nuclear DNA was assessed; a 32P-postlabeling assay proved that no DNA-adducts were detected in nuclear and mitochrondrial DNA in liver. No adverse effects were observed on rat organism. QBA had no influence on the gut mucosal epithelium, liver
- The subchronic safety of sanguiritrin, a mixture of sanguinarine (SA) and chelerythrine (CHE) quaternary benzo[c]phenanthridine alkaloids (QBA), obtained from Macleaya cordata was assessed. Rats were fed a diet containing 120 ppm sanguiritrin (100 ppm QBA) for 109 days. The feed consumption and the animal weight were monitored. The content of QBA in selected tissues and plasma was determined using HPLC. It was evidenced that 2 % of QBA were absorbed through the GIT while 98 % were excreted in the feces. In plasma, bilirubin, urea, creatinine, glomerular filtration, AST, ALT, GMT, ALP and total antioxidant capacity were determined. In liver, GSH level, lipoperoxidation products, SOD and GPx activities and total amount of cytochrome P450 were evaluated. Damage to nuclear DNA was assessed; a 32P-postlabeling assay proved that no DNA-adducts were detected in nuclear and mitochrondrial DNA in liver. No adverse effects were observed on rat organism. QBA had no influence on the gut mucosal epithelium, liver (en)
- Bezpečnost subchronické dávky sanguiritrinu, směsi kvarterních benzo[c]fenanthridinových alkaloidů (KBA) sanguinarinu (SA) a chelerythrinu (CHE), izolované z Macleaya cordata byla studována na potkanech. Potkani byli krmeni dietou obsahující 120 ppm sanguiritrinu (100 ppm KBA) po dobu 109 dní. Průběžně byla sledována spotřeba krmiva a hmotnost zvířat. Obsah KBA ve vybraných tkáních a v plasmě byl stanoven HPLC. Přibližně 2 % KBA byly absorbovány v GIT a 98 % bylo vyloučeno trusem. Hladina bilirubinu, močoviny, kreatininu, glomerulární filtrace, AST, ALT, GMT, ALP a celková antioxidační kapacita byly stanoveny v plasmě. V játrech bylo změřeno množství GSH, lipoperoxidačních produktů, aktivita SOD a GPx a celkové množství cytochromu P450. Poškození jaderné DNA bylo sledováno; metodou 32P-postlabelingu nebyly detekovány DNA-adukty v jaterní jaderné ani v mitochondriální DNA. Na potkanech nebyly pozorovány žádné nežádoucí změny. KBA nezpůsobily změny na epitelu střeva, jaterní tkáni a neovlivnily žádný z (cs)
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| Title
| - Safety assessment of sanguiritrin, alkaloid fraction of Macleya cordata, in rats
- Safety assessment of sanguiritrin, alkaloid fraction of Macleya cordata, in rats (en)
- Posouzení bezpečnosti sanguiritrinu, frakce alkaloidů z Macleaya cordata, na potkanech (cs)
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| skos:prefLabel
| - Safety assessment of sanguiritrin, alkaloid fraction of Macleya cordata, in rats
- Safety assessment of sanguiritrin, alkaloid fraction of Macleya cordata, in rats (en)
- Posouzení bezpečnosti sanguiritrinu, frakce alkaloidů z Macleaya cordata, na potkanech (cs)
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| skos:notation
| - RIV/61989592:15110/06:00003103!RIV07-GA0-15110___
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| http://linked.open.../vavai/riv/strany
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
| - P(GP203/03/D237), Z(MSM6198959216)
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
| - Lichnovský, Václav
- Šimánek, Vilím
- VEČEŘA, Rostislav
- VIČAR, Jaroslav
- Rajnochová Svobodová, Alena
- Ulrichová, Jitka
- Galandáková, Adéla
- Vostálová, Jitka
- Hrbáč, Jan
- Kosina, Pavel
- Jirovský, David
- Anzenbacherová, Eva
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/61989592:15110/06:00003103
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - Benzo[c]phenanthridine alkaloids; Oral administration; Biochemical markers; Oxidative stress; DNA damage; Cytochrome P450 (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...vavai/riv/projekt
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
| |
| http://linked.open...iv/tvurceVysledku
| - Kosina, Pavel
- Stiborová, Marie
- Ulrichová, Jitka
- Hrbáč, Jan
- Anzenbacherová, Eva
- Šimánek, Vilím
- Večeřa, Rostislav
- Jirovský, David
- Svobodová, Alena
- Vičar, Jaroslav
- Lichnovský, Václav
- Zdařilová, Adéla
- Psotová, Jitka
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| http://linked.open...n/vavai/riv/zamer
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| issn
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| number of pages
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| http://localhost/t...ganizacniJednotka
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| is http://linked.open...avai/riv/vysledek
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