About: Study of the inhibition of alpha-amylase by the benzo[c]phenanthridine alkaloids sanguinarine and chelerythrine

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About: Study of the inhibition of alpha-amylase by the benzo[c]phenanthridine alkaloids sanguinarine and chelerythrine Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Inhibition of porcine pancreas and human saliva alpha-amylase (EC 3.2. 1. 1) by sanguinarine and chelerythrine was studied. The inhibition of alpha-amylase was assayed using a biosensor method which utilises a flow system equipped with a peroxide electrode. 250 mu M sanguinarine and 250 mu M chelerythrine cause complete inhibition of 1.9 nkat alpha-amylase from porcine pancreas. The same concentration of sanguinarine and chelerythrine caused 23.9% and 7.5% inhibition, respectively, of 1.9 nkat alpha-amylase from human saliva. Mixed type and partially reversible inhibition was found for both alpha-amylases treated with either alkaloid. Inhibition of porcine pancreas and human saliva alpha-amylase (EC 3.2. 1. 1) by sanguinarine and chelerythrine was studied. The inhibition of alpha-amylase was assayed using a biosensor method which utilises a flow system equipped with a peroxide electrode. 250 mu M sanguinarine and 250 mu M chelerythrine cause complete inhibition of 1.9 nkat alpha-amylase from porcine pancreas. The same concentration of sanguinarine and chelerythrine caused 23.9% and 7.5% inhibition, respectively, of 1.9 nkat alpha-amylase from human saliva. Mixed type and partially reversible inhibition was found for both alpha-amylases treated with either alkaloid. (en)
Title	Study of the inhibition of alpha-amylase by the benzo[c]phenanthridine alkaloids sanguinarine and chelerythrine Study of the inhibition of alpha-amylase by the benzo[c]phenanthridine alkaloids sanguinarine and chelerythrine (en)
skos:prefLabel	Study of the inhibition of alpha-amylase by the benzo[c]phenanthridine alkaloids sanguinarine and chelerythrine Study of the inhibition of alpha-amylase by the benzo[c]phenanthridine alkaloids sanguinarine and chelerythrine (en)
skos:notation	RIV/61989592:15110/05:00002284!RIV12-MSM-15110___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GP303/01/P085), Z(MSM 151100003), Z(MSM6198959216)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	VIČAR, Jaroslav Ulrichová, Jitka Kosina, Pavel
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Palackého v Olomouci / Lékařská fakulta
http://linked.open...dnocenehoVysledku	545282
http://linked.open...ai/riv/idVysledku	RIV/61989592:15110/05:00002284
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	ISOAMYLASES; WHEAT; BARLEY; INSECT; SEEDS; PHASEOLUS-VULGARIS; MONOMERIC INHIBITOR; AMYLASE/SUBTILISIN INHIBITOR; PERFORMANCE LIQUID-CHROMATOGRAPHY; PORCINE PANCREATIC AMYLASE (en)
http://linked.open.../riv/klicoveSlovo	PERFORMANCE LIQUID-CHROMATOGRAPHY WHEAT INSECT AMYLASE/SUBTILISIN INHIBITOR BARLEY ISOAMYLASES MONOMERIC INHIBITOR PHASEOLUS-VULGARIS PORCINE PANCREATIC AMYLASE SEEDS
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[443F66F9703B]
http://linked.open...i/riv/nazevZdroje	Journal of Enzyme Inhibition and Medicinal Chemistry
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Cytotoxicity of some phytopreparations and dietary supplements
http://linked.open...UplatneniVysledku	2005
http://linked.open...v/svazekPeriodika	20
http://linked.open...iv/tvurceVysledku	Kosina, Pavel Ulrichová, Jitka Zajoncová, Ludmila Peč, Pavel Vičar, Jaroslav
http://linked.open...n/vavai/riv/zamer	Modulation of signalling and regulatory pathways in normal and cancer cells http://linked.opendata.cz/resource/domain/vavai/zamer/MSM%20151100003
issn	1475-6366
number of pages	7 (xsd:int)
http://localhost/t...ganizacniJednotka	15110

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