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| Description
| - Aberantní exprese růstových faktorů a jejich receptorů stromálními buňkami může být důležitým faktorem podporujícím růst solidních nádorů. Cílem studie bylo ověřit, zda bazický fibroblastový růstový faktor (bFGF) a růstový faktor krevních destiček (PDEGF) jsou zapojeny do vzájemných interakcí mezi nádorovým a stromálním mikroprostředím u primárních maligních melanomů. Výsledky naznačují, že bFGF a PDEGF participují na progresi maligního melanomu. (cs)
- Background: Aberrant expression of either growth factors or growth factor-receptors by stromal cells can be an important factor promoting the growth of solid tumours. It may also affect differentiation of malignant cells and support tumour spread. The aim of the present study was to investigate the hypothesis that basic-fibroblast growth factor (bFGF) and platelet-derived growth factor (PDEGF) may be involved in tumour-stromal microenvironment interactions in primary malignant melanomas. Materials and Methods: PDEGF and bFGF expression in malignant cells and surrounding stromal elements was assessed using indirect immunohistochemistry. Results: It was confirmed that PDEGF can be involved in the reciprocal interactions between tumour cells and stroma, including aberrant angiogenesis. Interestingly, bFGF was present both in malignant melanoma lesions and benign nevi accompanied by different intracellular localisation of the protein, suggesting its implication in regulation of nevus cell proliferation an
- Background: Aberrant expression of either growth factors or growth factor-receptors by stromal cells can be an important factor promoting the growth of solid tumours. It may also affect differentiation of malignant cells and support tumour spread. The aim of the present study was to investigate the hypothesis that basic-fibroblast growth factor (bFGF) and platelet-derived growth factor (PDEGF) may be involved in tumour-stromal microenvironment interactions in primary malignant melanomas. Materials and Methods: PDEGF and bFGF expression in malignant cells and surrounding stromal elements was assessed using indirect immunohistochemistry. Results: It was confirmed that PDEGF can be involved in the reciprocal interactions between tumour cells and stroma, including aberrant angiogenesis. Interestingly, bFGF was present both in malignant melanoma lesions and benign nevi accompanied by different intracellular localisation of the protein, suggesting its implication in regulation of nevus cell proliferation an (en)
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| Title
| - Molecular changes in PDEGF and bFGF in malignant melanomas in relation to the stromal microenvironment
- Molekulární změny v PDEGF a bFGF u maligních melanomů ve vztahu ke stromálnímu mikroprostředí (cs)
- Molecular changes in PDEGF and bFGF in malignant melanomas in relation to the stromal microenvironment (en)
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| skos:prefLabel
| - Molecular changes in PDEGF and bFGF in malignant melanomas in relation to the stromal microenvironment
- Molekulární změny v PDEGF a bFGF u maligních melanomů ve vztahu ke stromálnímu mikroprostředí (cs)
- Molecular changes in PDEGF and bFGF in malignant melanomas in relation to the stromal microenvironment (en)
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| skos:notation
| - RIV/61989592:15110/05:00002012!RIV06-MZ0-15110___
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| http://linked.open.../vavai/riv/strany
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/61989592:15110/05:00002012
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - malignant melanoma; microenvironment; PDEGF; bFGF (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...vavai/riv/projekt
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Tichý, Martin
- Kolář, Zdeněk
- Beneš, P.
- Brychtová, Světlana
- Hlobilková, Alice
- Fiurášková, Michala
- Sedláková, E.
- Zálešák, B.
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| http://localhost/t...ganizacniJednotka
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| is http://linked.open...avai/riv/vysledek
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