About: The MCP-1 −2518 (A to G) single nucleotide polymorphism is not associated with myocardial infarction in the Czech population     Goto   Sponge   NotDistinct   Permalink

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  • Monocyte chemoattractant protein (MCP)-1 is the keychemokine in the process of atheroslerotic vascularinflammation. Examining already reported associationbetween coronary artery disease (CAD) and the SNP A/Gin the MCP-1 gene (position −2518), 139 Czech patientswith CAD manifested as myocardial infarction (MI) and359 unrelated healthy control (C) subjects were genotypedby PCR-SSP. Genotype and allele frequencies werenot different in MI and C groups (allele G: MI, 20.5%; C,23.8%, OR = 0.8, P > 0.05). No differences were detectedwhen the patients were subdivided based on sex or theage of MI first occurrence. Further, no relationship wasobserved between circulating MCP-1 levels and carriageof the G allele. The data do not support a role for the MCP-1 −2518 single nucleotide polymorphism in susceptibilityto CAD manifested by myocardial infarction.
  • Monocyte chemoattractant protein (MCP)-1 is the keychemokine in the process of atheroslerotic vascularinflammation. Examining already reported associationbetween coronary artery disease (CAD) and the SNP A/Gin the MCP-1 gene (position −2518), 139 Czech patientswith CAD manifested as myocardial infarction (MI) and359 unrelated healthy control (C) subjects were genotypedby PCR-SSP. Genotype and allele frequencies werenot different in MI and C groups (allele G: MI, 20.5%; C,23.8%, OR = 0.8, P > 0.05). No differences were detectedwhen the patients were subdivided based on sex or theage of MI first occurrence. Further, no relationship wasobserved between circulating MCP-1 levels and carriageof the G allele. The data do not support a role for the MCP-1 −2518 single nucleotide polymorphism in susceptibilityto CAD manifested by myocardial infarction. (en)
  • Práce studuje souvislost polymorfismu genu pro chemokin MCP-1 (MCP-1-2518) ve vztahu k predispozici k aterosklerotickému postižení věnčitých tepen a infarktu myokardu. Asociační studie na 139 pacientech a 359 kontrolních jedincích nezjistila souvislost mezi uvedeným polymorfismem a infarktem myokardu v české populaci. (cs)
Title
  • The MCP-1 −2518 (A to G) single nucleotide polymorphism is not associated with myocardial infarction in the Czech population
  • The MCP-1 −2518 (A to G) single nucleotide polymorphism is not associated with myocardial infarction in the Czech population (en)
  • Jednonukleotidový polymorfismus MCP-1-2518 (A/G) nesouvisí s infarktem myokardu v české populaci (cs)
skos:prefLabel
  • The MCP-1 −2518 (A to G) single nucleotide polymorphism is not associated with myocardial infarction in the Czech population
  • The MCP-1 −2518 (A to G) single nucleotide polymorphism is not associated with myocardial infarction in the Czech population (en)
  • Jednonukleotidový polymorfismus MCP-1-2518 (A/G) nesouvisí s infarktem myokardu v české populaci (cs)
skos:notation
  • RIV/61989592:15110/05:00002005!RIV06-MZ0-15110___
http://linked.open.../vavai/riv/strany
  • 315-318
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(NI7308)
http://linked.open...iv/cisloPeriodika
  • 5
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 529146
http://linked.open...ai/riv/idVysledku
  • RIV/61989592:15110/05:00002005
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • MCP-1; polymorphism (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV
  • [16D9674FBAA2]
http://linked.open...i/riv/nazevZdroje
  • International Journal of Immunonegetics
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 32
http://linked.open...iv/tvurceVysledku
  • Drábek, Jiří
  • Mrázek, František
  • Petřek, Martin
  • Petřková, Jana
  • Čermáková, Z.
  • Lukl, Jan
  • Arakelyan, A.
issn
  • 1744-3121
number of pages
http://localhost/t...ganizacniJednotka
  • 15110
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