| Attributes | Values |
|---|
| rdf:type
| |
| Description
| - Aryl uhlovodíkový receptor (AhR), cytosolický protein náležejcí do rodiny jaderných receptorů, řídí transkripci široké škály strukturně nepříbuzných genů. K dnešnímu dni je nejsilnějším známým ligandem AhR - TCDD (2,3,7,8-tetrachlorodibenzo- p-dioxin). Expozice TCDD vede k množství toxických efektů, zejména pak k rozvoji nádorů a k potlačení imunity. Zdá se, že funkce AhR v buňkách a živých organismech je nezměrně důležitá. Absence AhR v geneticky manipulovaných myších vedla k závažným genotypickým abnormalitám, jako ke zmenšení velikosti jater a současně jaterní fibrose, akumulaci retinové kyseliny a k nedostatečnosti imunitního systému. Důležitá úloha AhR spočívá v tom, že transkripčně řídí některé biotransformační enzymy (CYP1A1/2,1B1). Tedy AhR je klíčovým faktorem v regulaci metabolismu xenobiotik. Za patofyziologických podmínek, jako je zánět, je snížená hladina a aktivita cílového genu AhR - CYP1A. Je tedy pravděpodobné, že mediátory a produkty zánětu ovlivňují funkci AhR. Toto review se zabývá (cs)
- The aryl hydrocarbon receptor (AhR), a cytosolic protein belonging to the family of nuclear receptors, controls transcription of a wide range of structurally unrelated genes. To date, the most potent AhR ligand is 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Exposure to TCDD leads to a number of toxic effects, in particular to tumor promotion and immunosuppression. The function of AhR in cells and living organisms therefore seems to be of paramount importance. Its absence in AhR null mice, results in severe phenotypic abnormalities, such as liver half size with fibrosis, accumulation of retinoic acid and immune system insufficiency. An important role of AhR inheres in its transcriptional control of several biotransformation enzymes (CYP1A1/2,1B1). Hence AhR is the crucial factor in the regulation of xenobiotic metabolism. Under pathophysiological conditions, such as inflammation, the level and activity of the AhR target gene CYP1A is decreased. Thus it is likely, that mediators and/or products of infla
- The aryl hydrocarbon receptor (AhR), a cytosolic protein belonging to the family of nuclear receptors, controls transcription of a wide range of structurally unrelated genes. To date, the most potent AhR ligand is 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Exposure to TCDD leads to a number of toxic effects, in particular to tumor promotion and immunosuppression. The function of AhR in cells and living organisms therefore seems to be of paramount importance. Its absence in AhR null mice, results in severe phenotypic abnormalities, such as liver half size with fibrosis, accumulation of retinoic acid and immune system insufficiency. An important role of AhR inheres in its transcriptional control of several biotransformation enzymes (CYP1A1/2,1B1). Hence AhR is the crucial factor in the regulation of xenobiotic metabolism. Under pathophysiological conditions, such as inflammation, the level and activity of the AhR target gene CYP1A is decreased. Thus it is likely, that mediators and/or products of infla (en)
|
| Title
| - Status aromatického uhlovodíkového receptoru v metabolismu xenobiotik za normálních a pathofyziologických podmínek (cs)
- Aromatic hydrocarbon receptor status in the metabolism of xenobiotics under normal and pathophysiological conditions
- Aromatic hydrocarbon receptor status in the metabolism of xenobiotics under normal and pathophysiological conditions (en)
|
| skos:prefLabel
| - Status aromatického uhlovodíkového receptoru v metabolismu xenobiotik za normálních a pathofyziologických podmínek (cs)
- Aromatic hydrocarbon receptor status in the metabolism of xenobiotics under normal and pathophysiological conditions
- Aromatic hydrocarbon receptor status in the metabolism of xenobiotics under normal and pathophysiological conditions (en)
|
| skos:notation
| - RIV/61989592:15110/04:00001791!RIV06-MSM-15110___
|
| http://linked.open.../vavai/riv/strany
| |
| http://linked.open...avai/riv/aktivita
| |
| http://linked.open...avai/riv/aktivity
| - P(GP303/04/P074), Z(MSM 151100003)
|
| http://linked.open...iv/cisloPeriodika
| |
| http://linked.open...vai/riv/dodaniDat
| |
| http://linked.open...aciTvurceVysledku
| |
| http://linked.open.../riv/druhVysledku
| |
| http://linked.open...iv/duvernostUdaju
| |
| http://linked.open...titaPredkladatele
| |
| http://linked.open...dnocenehoVysledku
| |
| http://linked.open...ai/riv/idVysledku
| - RIV/61989592:15110/04:00001791
|
| http://linked.open...riv/jazykVysledku
| |
| http://linked.open.../riv/klicovaSlova
| - AhR receptor; regulation; xenobiotics; metabolism; infl ammation (en)
|
| http://linked.open.../riv/klicoveSlovo
| |
| http://linked.open...odStatuVydavatele
| |
| http://linked.open...ontrolniKodProRIV
| |
| http://linked.open...i/riv/nazevZdroje
| |
| http://linked.open...in/vavai/riv/obor
| |
| http://linked.open...ichTvurcuVysledku
| |
| http://linked.open...cetTvurcuVysledku
| |
| http://linked.open...vavai/riv/projekt
| |
| http://linked.open...UplatneniVysledku
| |
| http://linked.open...v/svazekPeriodika
| |
| http://linked.open...iv/tvurceVysledku
| - Dvořák, Zdeněk
- Ulrichová, Jitka
- Vrzal, Radim
|
| http://linked.open...n/vavai/riv/zamer
| |
| issn
| |
| number of pages
| |
| http://localhost/t...ganizacniJednotka
| |
![[RDF Data]](/fct/images/sw-rdf-blue.png)
![[cxml]](/fct/images/cxml_doc.png)
![[csv]](/fct/images/csv_doc.png)
![[text]](/fct/images/ntriples_doc.png)
![[turtle]](/fct/images/n3turtle_doc.png)
![[ld+json]](/fct/images/jsonld_doc.png)
![[rdf+json]](/fct/images/json_doc.png)
![[rdf+xml]](/fct/images/xml_doc.png)
![[atom+xml]](/fct/images/atom_doc.png)
![[html]](/fct/images/html_doc.png)