About: Effects of polyphenols from Silybum marianum on UVA-induced apoptosis and DNA damage in human skin cells     Goto   Sponge   NotDistinct   Permalink

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Description
  • Předkládaná studie ukazuje, že extrakt z Silybum marianum (L.) a jeho flavonolignany silybin a dehydrosilybin jsou schopny ochránit lidské keratinocyty před buněčnou smrtí, DNA poškozením a apoptosou vyvolanými UVA zářením. Protektivní schopnosti těchto látek jsou dány jejich antioxidačními vlastnostmi. (cs)
  • The present study clearly shows that silymarin, an extract from Silybum marianum (L.) and its flavonolignans silybin and dehydrosilybin prevent UVA-induced cell death, DNA damage and development of apoptosis in human keratinocytes. The antioxidant action of the compounds seems to be involved in protective mechanisms. The results demonstrate the ability of the studied compounds to modify oxidative stress induced by UVA radiation in the skin.
  • The present study clearly shows that silymarin, an extract from Silybum marianum (L.) and its flavonolignans silybin and dehydrosilybin prevent UVA-induced cell death, DNA damage and development of apoptosis in human keratinocytes. The antioxidant action of the compounds seems to be involved in protective mechanisms. The results demonstrate the ability of the studied compounds to modify oxidative stress induced by UVA radiation in the skin. (en)
Title
  • Vliv polyfenolů ze Silybum marianum na UVA-indukovanou apoptosu a poškození DNA v lidských kožních buňkách (cs)
  • Effects of polyphenols from Silybum marianum on UVA-induced apoptosis and DNA damage in human skin cells
  • Effects of polyphenols from Silybum marianum on UVA-induced apoptosis and DNA damage in human skin cells (en)
skos:prefLabel
  • Vliv polyfenolů ze Silybum marianum na UVA-indukovanou apoptosu a poškození DNA v lidských kožních buňkách (cs)
  • Effects of polyphenols from Silybum marianum on UVA-induced apoptosis and DNA damage in human skin cells
  • Effects of polyphenols from Silybum marianum on UVA-induced apoptosis and DNA damage in human skin cells (en)
skos:notation
  • RIV/61989592:15110/04:00000841!RIV/2005/GA0/151105/N
http://linked.open.../vavai/riv/strany
  • 91-92
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(GA303/02/1097), Z(MSM 151100003)
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 562189
http://linked.open...ai/riv/idVysledku
  • RIV/61989592:15110/04:00000841
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • Silymarin;flavonolignans;keratinocyte;UVA;oxidative stress;DNA damage (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...ontrolniKodProRIV
  • [FDD9544D6D4A]
http://linked.open...i/riv/mistoVydani
  • Helsinky, Finland
http://linked.open...i/riv/nazevZdroje
  • XXII International Conference on Polyphenols, August 25-28
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...iv/tvurceVysledku
  • Svobodová, Alena
  • Walterová, Daniela
  • Zdařilová, Adéla
  • Psotová, Jitka
http://linked.open...n/vavai/riv/zamer
number of pages
http://purl.org/ne...btex#hasPublisher
  • University of Helsinki
https://schema.org/isbn
  • 952-10-1977-8
http://localhost/t...ganizacniJednotka
  • 15110
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