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| Description
| - Flavonoids are found universally in plants and act as free radical scavenging and chelating agents with antiinflammatory, antiischemic, vasodilating and chemoprotective properties. In this study, the antilipoperoxidative and cytoprotective effects of apigenin, baicalein, kaempferol, luteolin and quercetin against doxorubicin-induced oxidative stress were investigated in isolated rat heart cardiac myocytes, mitochondria and microsomes. After preincubation of cardiomyocytes with the test compounds for 1 h the cardiomyocytes were treated with the toxic agent, doxorubicin (100 micro M for 8 h). Cardiomyocyte protection was assessed by extracellular LDH and cellular ADP and ATP production. Cytoprotection was concentration dependent for baicalein > luteolin congruent with apigenin > quercetin > kaempferol. All test compounds had signi fi cantly better protective effects than dexrazoxan, an agent currently used for adjuvant therapy during anthracycline antibiotic therapy. In microsomes/mitochondria the IC(50
- Flavonoids are found universally in plants and act as free radical scavenging and chelating agents with antiinflammatory, antiischemic, vasodilating and chemoprotective properties. In this study, the antilipoperoxidative and cytoprotective effects of apigenin, baicalein, kaempferol, luteolin and quercetin against doxorubicin-induced oxidative stress were investigated in isolated rat heart cardiac myocytes, mitochondria and microsomes. After preincubation of cardiomyocytes with the test compounds for 1 h the cardiomyocytes were treated with the toxic agent, doxorubicin (100 micro M for 8 h). Cardiomyocyte protection was assessed by extracellular LDH and cellular ADP and ATP production. Cytoprotection was concentration dependent for baicalein > luteolin congruent with apigenin > quercetin > kaempferol. All test compounds had signi fi cantly better protective effects than dexrazoxan, an agent currently used for adjuvant therapy during anthracycline antibiotic therapy. In microsomes/mitochondria the IC(50 (en)
- Flavonoidy jsou hojně rozšířeny v rostlinách a reagují jako zhášeče volných radikálů a chelatační činidla s protizánětlivými, antiischemickými, vasodilatačními a chemoprotektivními vlastnostmi. V této studii byla zjišťována schopnost apigeninu, baicaleinu, kampferolu, luteolinu a kvercetinu potlačit peroxidaci lipidů a oxidativní stres vyvolaný doxorubicinem na isolovaných kardiomyocytech, mitochondriích a mikrosomech. Po preinkubaci kardiomyocytů s testovanými látkami 1 hod byly kardiomyocyty intoxikovány doxorubicinem (100 mM po 8 hod). Ochrana kardiomyocytů byla sledována hladinou extracelulární LDH a obsahem ADP a ATP v buňce. Cytoprotektivita látek byla koncentračně závislá, baicalein>luteolin@apigenin>kvercetin> kamferol. Všechny látky vykázaly signifikantně lepší protektivní účinek než dexrazoxan, který je v současné době používán v podpůrné terapii při léčbě antracyklinovými antibiotiky. Hodnota IC50 testovaných látek na modelu lipoperoxidačního poškození mikrosomů/mitochondrií byla pro kv (cs)
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| Title
| - Chemoprotektivní vliv rostlinných fenolů vůči toxicitě indukované anthracykliny v potkaních kardiomyocytech. Část III. Apigenin, baicalelin, kamferol, luteolin a kvercetin (cs)
- Chemoprotective effect of plant phenolics against anthracycline-induced toxicity on rat cardiomyocytes. Part III. Apigenin, baicalelin, kaempherol, luteolin and quercetin
- Chemoprotective effect of plant phenolics against anthracycline-induced toxicity on rat cardiomyocytes. Part III. Apigenin, baicalelin, kaempherol, luteolin and quercetin (en)
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| skos:prefLabel
| - Chemoprotektivní vliv rostlinných fenolů vůči toxicitě indukované anthracykliny v potkaních kardiomyocytech. Část III. Apigenin, baicalelin, kamferol, luteolin a kvercetin (cs)
- Chemoprotective effect of plant phenolics against anthracycline-induced toxicity on rat cardiomyocytes. Part III. Apigenin, baicalelin, kaempherol, luteolin and quercetin
- Chemoprotective effect of plant phenolics against anthracycline-induced toxicity on rat cardiomyocytes. Part III. Apigenin, baicalelin, kaempherol, luteolin and quercetin (en)
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| skos:notation
| - RIV/61989592:15110/04:00000835!RIV/2005/MSM/151105/N
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| http://linked.open.../vavai/riv/strany
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
| - Z(MSM 151100003), Z(MSM 153100007)
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/61989592:15110/04:00000835
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - Flavonoid;doxorubicin;rat cardiomyocytes;lipid peroxidation;cyclic voltammetry;scavenging effect;cytoprotection (en)
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| http://linked.open.../riv/klicoveSlovo
| |
| http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
| |
| http://linked.open...UplatneniVysledku
| |
| http://linked.open...v/svazekPeriodika
| |
| http://linked.open...iv/tvurceVysledku
| - Hrbáč, Jan
- Šimánek, Vilím
- Psotová, Jitka
- Chlopčíková, Šárka
- Miketová, P.
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| http://linked.open...n/vavai/riv/zamer
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| issn
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| number of pages
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| http://localhost/t...ganizacniJednotka
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