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  • Background: Chemokine-driven migration of inflammatory cells has been implicated in the pathogenesis of atherosclerotic conditions including peripheral arterial disease (PAD). Monocyte chemoattractant protein-1 (MCP-1) is elevated in patients with coronary artery disease and in hypertensive patients. This study therefore investigated MCP-1 in patients with PAD.Methods: Serum MCP-1 was determined by enzymelinked immunosorbent assay in 36 healthy, control subjects and in 19 patients with PAD. Statistical analysis utilised the Mann /Whitney test and Spearman correlation (pB/0.05). Results: MCP-1 (pg/ml) was increased in patients compared with in controls (mean9/standard error of the mean: PAD group, 7489/60; control group, 4599/ 27; p /0.0001). MCP-1 levels tended to decrease with progressing disease. From atherosclerosis risk factors, diabetes inclined to increase MCP-1 levels; hypertension had no effect. Serum MCP-1 correlated with cholesterol, triglycerides, low-density lipoprotein but not high-dens
  • Background: Chemokine-driven migration of inflammatory cells has been implicated in the pathogenesis of atherosclerotic conditions including peripheral arterial disease (PAD). Monocyte chemoattractant protein-1 (MCP-1) is elevated in patients with coronary artery disease and in hypertensive patients. This study therefore investigated MCP-1 in patients with PAD.Methods: Serum MCP-1 was determined by enzymelinked immunosorbent assay in 36 healthy, control subjects and in 19 patients with PAD. Statistical analysis utilised the Mann /Whitney test and Spearman correlation (pB/0.05). Results: MCP-1 (pg/ml) was increased in patients compared with in controls (mean9/standard error of the mean: PAD group, 7489/60; control group, 4599/ 27; p /0.0001). MCP-1 levels tended to decrease with progressing disease. From atherosclerosis risk factors, diabetes inclined to increase MCP-1 levels; hypertension had no effect. Serum MCP-1 correlated with cholesterol, triglycerides, low-density lipoprotein but not high-dens (en)
  • Chemicky vyvolaná migrace zánětlivých buněk byla implikována při patogenezi aterosklerotických stavů, včetně periferního arteriálního onemocnění (PAD). Hladina monocyt-chemoattractant proteinu-1 (MCP-1) se zvyšuje u pacientů s (cs)
Title
  • Monocyte chemoattractant protein-1 in patients with peripheral arterial disease
  • Monocyte chemoattractant protein-1 in patients with peripheral arterial disease (en)
  • Chemokin MCP-1 u pacientů s ischemickou chorobou dolních končetin (cs)
skos:prefLabel
  • Monocyte chemoattractant protein-1 in patients with peripheral arterial disease
  • Monocyte chemoattractant protein-1 in patients with peripheral arterial disease (en)
  • Chemokin MCP-1 u pacientů s ischemickou chorobou dolních končetin (cs)
skos:notation
  • RIV/61989592:15110/04:00000834!RIV/2005/MZ0/151105/N
http://linked.open.../vavai/riv/strany
  • 39-43
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(NI7308), Z(MSM 151100002)
http://linked.open...iv/cisloPeriodika
  • 1
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 574523
http://linked.open...ai/riv/idVysledku
  • RIV/61989592:15110/04:00000834
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • Monocyte chemoattractant protein-1;CC;chemokine ligand 2;Atherosclerosis;Artheritis obliterans;Risk factors;Low-density lipoprotein (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV
  • [F7A51525F12F]
http://linked.open...i/riv/nazevZdroje
  • Mediators of Inflammatory
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 13
http://linked.open...iv/tvurceVysledku
  • Heřmanová, Zuzana
  • Petřek, Martin
  • Petřková, Jana
  • Lukl, Jan
  • Szotkowská, Jaroslava
http://linked.open...n/vavai/riv/zamer
issn
  • 0962-9351
number of pages
http://localhost/t...ganizacniJednotka
  • 15110
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