About: Pharmacokinetic study of iodine-labeled silibinins in rat

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About: Pharmacokinetic study of iodine-labeled silibinins in rat Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Nízká dostupnost silibininu, hlavní antioxidační flavonolignan silymarinu z Silybum marianum L. (Asteraceae), vyžaduje citlivé metody ke studiu modulace biologické dostupnosti silibininu. (cs) The very low bioavailability of silibinin (silybin, SB), the main antioxidant flavonolignan of silymarin from Silybum marianum L. (Asteraceae), requires sensitive methods to study the modulation of silibinin bioavailability. To evaluate the potential for use of radiolabeled silibinin, two silibinin derivatives, separated by HPLC after iodination (125I- SB1and125I- SB2) and their complexes 1 : 1 with phosphatidylcholine (125I- SPC1and125I- SPC2) were administered concurrently with a single intragastric dose of 5.0 mg or 50 mg of unlabeled silibinin (alone or as a constituent of the complex) per kg of body weight in a comparative study of bioavailability in the rat. Pharmacokinetic parameters as well as organ uptake of125I- SB1-derived radioactivity showed a dose?response pattern. The parameters of bioavailability after125I- SPC1intake were not influenced by unlabeled silibinin (complexed with phosphatidylcholine), since maximal levels were achieved by the lower dose of unlabeled compound. The superior The very low bioavailability of silibinin (silybin, SB), the main antioxidant flavonolignan of silymarin from Silybum marianum L. (Asteraceae), requires sensitive methods to study the modulation of silibinin bioavailability. To evaluate the potential for use of radiolabeled silibinin, two silibinin derivatives, separated by HPLC after iodination (125I- SB1and125I- SB2) and their complexes 1 : 1 with phosphatidylcholine (125I- SPC1and125I- SPC2) were administered concurrently with a single intragastric dose of 5.0 mg or 50 mg of unlabeled silibinin (alone or as a constituent of the complex) per kg of body weight in a comparative study of bioavailability in the rat. Pharmacokinetic parameters as well as organ uptake of125I- SB1-derived radioactivity showed a dose?response pattern. The parameters of bioavailability after125I- SPC1intake were not influenced by unlabeled silibinin (complexed with phosphatidylcholine), since maximal levels were achieved by the lower dose of unlabeled compound. The superior (en)
Title	Farmakokinetická studie silibininů značených jódem u potkana (cs) Pharmacokinetic study of iodine-labeled silibinins in rat Pharmacokinetic study of iodine-labeled silibinins in rat (en)
skos:prefLabel	Farmakokinetická studie silibininů značených jódem u potkana (cs) Pharmacokinetic study of iodine-labeled silibinins in rat Pharmacokinetic study of iodine-labeled silibinins in rat (en)
skos:notation	RIV/61989592:15110/01:00006008!RIV09-MZ0-15110___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(NL6713), Z(MSM 151100003)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2009
http://linked.open...aciTvurceVysledku	Šimánek, Vilím ŠKOTTOVÁ, Nina VEČEŘA, Rostislav Urbánek, Karel
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Palackého v Olomouci / Lékařská fakulta
http://linked.open...dnocenehoVysledku	691046
http://linked.open...ai/riv/idVysledku	RIV/61989592:15110/01:00006008
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	silibinin; silibinin; phosphatidylcholine complex; bioavailability (en)
http://linked.open.../riv/klicoveSlovo	silibinin phosphatidylcholine complex bioavailability
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[62FAA80101A1]
http://linked.open...i/riv/nazevZdroje	Pharmacological Research
http://linked.open...in/vavai/riv/obor	FR
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Experimental pharmacology of antioxidants and hypolipidemics on the basis of standarized mixtures of polyphenols from Silybum marianum and Prunella vulgaris
http://linked.open...UplatneniVysledku	2001
http://linked.open...v/svazekPeriodika	44
http://linked.open...iv/tvurceVysledku	Urbánek, Karel Šimánek, Vilím Večeřa, Rostislav Škottová, Nina Švagera, Zdeněk Jegorov, Alexander
http://linked.open...n/vavai/riv/zamer	http://linked.opendata.cz/resource/domain/vavai/zamer/MSM%20151100003
issn	1043-6618
number of pages	7 (xsd:int)
http://localhost/t...ganizacniJednotka	15110

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