About: Biotransformation of silybin diastereomer A in rat and porcine hepatocytes

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About: Biotransformation of silybin diastereomer A in rat and porcine hepatocytes Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Silybin, the main flavonolignan from Silybum marianum, is well recognized as an antioxidant and free radiacal scavenger with the capacity for regenerating liver cells. The aim of the present contribution was to investigate silybin conjugate formation in primary cultures of rat and porcine hepatocytes. For silybin determination HPLC method with SPE was used with several glucuronides of silybin standards. The amount of total conjugated silybin was evaluated after enzymatic cleavage. Several hydrophylic metabolites of silybin, namely glucuronides and sulphates, were found. Prefered position of transformation was 7 and 20 of diastereomer A. Silybin, the main flavonolignan from Silybum marianum, is well recognized as an antioxidant and free radiacal scavenger with the capacity for regenerating liver cells. The aim of the present contribution was to investigate silybin conjugate formation in primary cultures of rat and porcine hepatocytes. For silybin determination HPLC method with SPE was used with several glucuronides of silybin standards. The amount of total conjugated silybin was evaluated after enzymatic cleavage. Several hydrophylic metabolites of silybin, namely glucuronides and sulphates, were found. Prefered position of transformation was 7 and 20 of diastereomer A. (en) Silybin, hlavní flavonolignan Silybum marianum, je známý jako antioxidant a lapač volných radikálů se schopností regenerace jaterních buněk. Cílem práce bylo sledování produkce konjugátů silybinu v primárních kulturách potkaních a prasečích hepatocytů. Pro stanovení silybinu a jeho metabolitů byla použita HPLC metoda s extrakcí na pevnou fázi a několik standardů glukuronidů silybinu. Celkové množství konjugovaného silybinu bylo zjišťováno po enzymatickém štěpení. Bylo nalezeno několik hydrofilních derivátů, glukuronidů a sulfátů. Preferovaná pozice metabolizace diastereomeru A byla 7 a 20. (cs)
Title	Biotransformation of silybin diastereomer A in rat and porcine hepatocytes Biotransformation of silybin diastereomer A in rat and porcine hepatocytes (en) Biotransformace diastereomeru A silybinu v potkaních a prasečích hepatocytech (cs)
skos:prefLabel	Biotransformation of silybin diastereomer A in rat and porcine hepatocytes Biotransformation of silybin diastereomer A in rat and porcine hepatocytes (en) Biotransformace diastereomeru A silybinu v potkaních a prasečích hepatocytech (cs)
skos:notation	RIV/61989592:15110/00:00006976!RIV09-MSM-15110___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA303/98/0414), P(GA311/98/0648), P(VS96021), Z(MSM 151100003)
http://linked.open...iv/cisloPeriodika	8
http://linked.open...vai/riv/dodaniDat	2009
http://linked.open...aciTvurceVysledku	Walterová, Daniela Ulrichová, Jitka Kosina, Pavel
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Palackého v Olomouci / Lékařská fakulta
http://linked.open...dnocenehoVysledku	705811
http://linked.open...ai/riv/idVysledku	RIV/61989592:15110/00:00006976
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Silybin; biotransformation; rat hepatocytes; porcine hepatocytes (en)
http://linked.open.../riv/klicoveSlovo	rat hepatocytes Silybin porcine hepatocytes biotransformation
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[2FFAD428517A]
http://linked.open...i/riv/nazevZdroje	Chemické listy
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Selected natural compounds as protective agents against chemically induced human hepatocyte injury Optimization of Isolatinion, Cultivation, Enkapsulation, and Cryopreservation of Human Hepatocytes with the Prospect of Allotransplantaion Centrum for Analytical Chemistry of Molecular Structure
http://linked.open...UplatneniVysledku	2000
http://linked.open...v/svazekPeriodika	94
http://linked.open...iv/tvurceVysledku	Dvořák, Zdeněk Kosina, Pavel Ulrichová, Jitka Walterová, Daniela
http://linked.open...n/vavai/riv/zamer	http://linked.opendata.cz/resource/domain/vavai/zamer/MSM%20151100003
issn	0009-2770
number of pages	1 (xsd:int)
http://localhost/t...ganizacniJednotka	15110

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