About: Preparation of Risedronate Nanoparticles by Solvent Evaporation Technique

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://www.mdpi.com/1420-3049/19/11/17848
Description	One approach for the enhancement of oral drug bioavailability is the technique of nanoparticle preparation. Risedronate sodium (Biopharmaceutical Classification System Class III) was chosen as a model compound with high water solubility and low intestinal permeability. Eighteen samples of risedronate sodium were prepared by the solvent evaporation technique with sodium dodecyl sulfate, polysorbate, macrogol, sodium carboxymethyl cellulose and sodium carboxymethyl dextran as nanoparticle stabilizers applied in three concentrations. The prepared samples were characterized by dynamic light scattering and scanning electron microscopy. Fourier transform mid-infrared spectroscopy was used for verification of the composition of the samples. The particle size of sixteen samples was less than 200 nm. Polysorbate, sodium carboxymethyl dextran and macrogol were determined as the most favourable excipients; the particle size of the samples of risedronate with these excipients ranged from 2.8 to 10.5 nm. One approach for the enhancement of oral drug bioavailability is the technique of nanoparticle preparation. Risedronate sodium (Biopharmaceutical Classification System Class III) was chosen as a model compound with high water solubility and low intestinal permeability. Eighteen samples of risedronate sodium were prepared by the solvent evaporation technique with sodium dodecyl sulfate, polysorbate, macrogol, sodium carboxymethyl cellulose and sodium carboxymethyl dextran as nanoparticle stabilizers applied in three concentrations. The prepared samples were characterized by dynamic light scattering and scanning electron microscopy. Fourier transform mid-infrared spectroscopy was used for verification of the composition of the samples. The particle size of sixteen samples was less than 200 nm. Polysorbate, sodium carboxymethyl dextran and macrogol were determined as the most favourable excipients; the particle size of the samples of risedronate with these excipients ranged from 2.8 to 10.5 nm. (en)
Title	Preparation of Risedronate Nanoparticles by Solvent Evaporation Technique Preparation of Risedronate Nanoparticles by Solvent Evaporation Technique (en)
skos:prefLabel	Preparation of Risedronate Nanoparticles by Solvent Evaporation Technique Preparation of Risedronate Nanoparticles by Solvent Evaporation Technique (en)
skos:notation	RIV/61989100:27640/14:86092431!RIV15-MSM-27640___
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(ED1.1.00/02.0070), P(GAP304/11/2246)
http://linked.open...iv/cisloPeriodika	11
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Dědková, Kateřina Plachá, Daniela Peikertová, Pavlína
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Vysoká škola báňská - Technická univerzita Ostrava / Centrum nanotechnologií
http://linked.open...dnocenehoVysledku	39052
http://linked.open...ai/riv/idVysledku	RIV/61989100:27640/14:86092431
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	SEM; FTIR; DLS; solvent evaporation; excipients; nanoparticles; risedronate sodium (en)
http://linked.open.../riv/klicoveSlovo	SEM FTIR nanoparticles excipients DLS solvent evaporation risedronate sodium
http://linked.open...odStatuVydavatele	CH - Švýcarská konfederace
http://linked.open...ontrolniKodProRIV	[8646ADB1E79A]
http://linked.open...i/riv/nazevZdroje	Molecules
http://linked.open...in/vavai/riv/obor	FR
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	Nanotechnology Approaches for Drug Delivery Across Blood-Tissue Barriers IT4Innovations Centre of Excellence
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	19
http://linked.open...iv/tvurceVysledku	Jampílek, Josef Plachá, Daniela Peikertová, Pavlína Vaculíková, Eliška Dědková, Kateřina Devinský, Ferdinand Pisarčík, Martin
http://linked.open...ain/vavai/riv/wos	000345564300045
issn	1420-3049
number of pages	14 (xsd:int)
http://bibframe.org/vocab/doi	10.3390/molecules191117848
http://localhost/t...ganizacniJednotka	27640

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