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  • The aim was to detect antimutagenic and DNA protective effects of a plant extract from bark of Magnolia officinalis adversing oxidative DNA damage. The ability to inhibit mutagenicity induced by tert-butyl hydroperoxide (t-BOOH) and hydrogen peroxide (H2O2) was determined with Ames test using Salmonella typhimurium His- TA102 bacterial strain. Inhibition values of 72.8 and 98.7 % were detected for t-BOOH and H2O2, respectively. The protective effect of the extract against DNA strand scission induced by hydroxyl radicals was studied with plasmid pBluescript II SK(-). The analysis of DNA strand breaks in the plasmid DNA proved a significant inhibition of DNA damage.
  • The aim was to detect antimutagenic and DNA protective effects of a plant extract from bark of Magnolia officinalis adversing oxidative DNA damage. The ability to inhibit mutagenicity induced by tert-butyl hydroperoxide (t-BOOH) and hydrogen peroxide (H2O2) was determined with Ames test using Salmonella typhimurium His- TA102 bacterial strain. Inhibition values of 72.8 and 98.7 % were detected for t-BOOH and H2O2, respectively. The protective effect of the extract against DNA strand scission induced by hydroxyl radicals was studied with plasmid pBluescript II SK(-). The analysis of DNA strand breaks in the plasmid DNA proved a significant inhibition of DNA damage. (en)
Title
  • Antigenotoxic effects of a bark extract from Magnolia officinalis
  • Antigenotoxic effects of a bark extract from Magnolia officinalis (en)
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  • Antigenotoxic effects of a bark extract from Magnolia officinalis
  • Antigenotoxic effects of a bark extract from Magnolia officinalis (en)
skos:notation
  • RIV/61988987:17310/12:A13017G5!RIV13-MSM-17310___
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  • P(ED2.1.00/03.0100)
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  • 1
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  • 122948
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  • RIV/61988987:17310/12:A13017G5
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  • Ames test; Antimutagenicity; DNA strand scission; Magnolia officinalis (en)
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  • CZ - Česká republika
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  • [418926B1DD52]
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  • 3
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  • Malachová, Kateřina
  • Rybková, Zuzana
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  • 1211-3026
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  • 17310
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