About: The role of histone deacetylase inhibitors in patients with relapsed/refractory multiple myeloma     Goto   Sponge   NotDistinct   Permalink

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Description
  • Clinical outcomes for patients with multiple myeloma (MM) have improved substantially since the introduction of novel agents including the proteasome inhibitor bortezomib and the immunomodulatory drugs thalidomide and lenalidomide. However, most patients with MM eventually relapse, and prognosis remains poor among patients with relapsed and/or refractory disease. Combination therapy using agents with different mechanisms of action is emerging as an attractive treatment approach in oncology to increase efficacy and/or overcome resistance to standard treatment regimens. This review discusses unmet needs in the treatment of MM and the development of histone deacetylase inhibitors as a treatment modality for MM.
  • Clinical outcomes for patients with multiple myeloma (MM) have improved substantially since the introduction of novel agents including the proteasome inhibitor bortezomib and the immunomodulatory drugs thalidomide and lenalidomide. However, most patients with MM eventually relapse, and prognosis remains poor among patients with relapsed and/or refractory disease. Combination therapy using agents with different mechanisms of action is emerging as an attractive treatment approach in oncology to increase efficacy and/or overcome resistance to standard treatment regimens. This review discusses unmet needs in the treatment of MM and the development of histone deacetylase inhibitors as a treatment modality for MM. (en)
Title
  • The role of histone deacetylase inhibitors in patients with relapsed/refractory multiple myeloma
  • The role of histone deacetylase inhibitors in patients with relapsed/refractory multiple myeloma (en)
skos:prefLabel
  • The role of histone deacetylase inhibitors in patients with relapsed/refractory multiple myeloma
  • The role of histone deacetylase inhibitors in patients with relapsed/refractory multiple myeloma (en)
skos:notation
  • RIV/61988987:17110/14:A1501CGS!RIV15-MSM-17110___
http://linked.open...avai/riv/aktivita
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  • 43125
http://linked.open...ai/riv/idVysledku
  • RIV/61988987:17110/14:A1501CGS
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • Multiple myeloma; histone deacetylase inhibitor; proteasome inhibitor; immunomodulatory drug; bortezomib (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV
  • [EAD859DD11CD]
http://linked.open...i/riv/nazevZdroje
  • Leukemia & Lymphoma
http://linked.open...in/vavai/riv/obor
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http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 55
http://linked.open...iv/tvurceVysledku
  • Hájek, Roman
  • Orlowski, Robert Z.
  • Palumbo, Antonio
  • Ludwig, Heinz
  • Dimopoulos, Meletios
  • Siegel, David
issn
  • 1042-8194
number of pages
http://localhost/t...ganizacniJednotka
  • 17110
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