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  • Administration of anaesthesia during the daytime is important and may influence specific aspects of in vivo animal experiments. The aim of the present study was to refer to the suitability of the use of ketamine/xylazine anaesthesia in chronobiological studies. Study was performed in ketamine-/xylazine-anaesthetized female Wistar rats ( 100 mg/kg/15 mg/kg, i.m) after adaptation to a light-dark (LD) cycle ( 12 h: 12 h). Heart rate (HR), rectal temperature, ECG parameters, autonomic nervous system activity, acid-base balance and Na+, K+, Ca2+ and Cl(-)plasma concentrations were evaluated in dependence on LD cycle. LD differences were found in the HR, rectal temperature, RR, PQ and QTc intervals, QRS complex, P wave amplitude, in power HF, LF and VLF components, in paO2 and HCO3-, and in Na+, Cl(-)and Ca2+ ions. Ketamine/xylazine anaesthesia may be applicable in chronobiological studies. It does not disturb LD differences, but it can modify them probably without loss of rhythmicity.
  • Administration of anaesthesia during the daytime is important and may influence specific aspects of in vivo animal experiments. The aim of the present study was to refer to the suitability of the use of ketamine/xylazine anaesthesia in chronobiological studies. Study was performed in ketamine-/xylazine-anaesthetized female Wistar rats ( 100 mg/kg/15 mg/kg, i.m) after adaptation to a light-dark (LD) cycle ( 12 h: 12 h). Heart rate (HR), rectal temperature, ECG parameters, autonomic nervous system activity, acid-base balance and Na+, K+, Ca2+ and Cl(-)plasma concentrations were evaluated in dependence on LD cycle. LD differences were found in the HR, rectal temperature, RR, PQ and QTc intervals, QRS complex, P wave amplitude, in power HF, LF and VLF components, in paO2 and HCO3-, and in Na+, Cl(-)and Ca2+ ions. Ketamine/xylazine anaesthesia may be applicable in chronobiological studies. It does not disturb LD differences, but it can modify them probably without loss of rhythmicity. (en)
Title
  • Ketamine/xylazine anaesthesia in the chronobiological studies
  • Ketamine/xylazine anaesthesia in the chronobiological studies (en)
skos:prefLabel
  • Ketamine/xylazine anaesthesia in the chronobiological studies
  • Ketamine/xylazine anaesthesia in the chronobiological studies (en)
skos:notation
  • RIV/61988987:17110/14:A1501BT8!RIV15-MSM-17110___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • I
http://linked.open...iv/cisloPeriodika
  • 4
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 24194
http://linked.open...ai/riv/idVysledku
  • RIV/61988987:17110/14:A1501BT8
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • ketamine/xylazine; chronobiology; electrophysiology of the heart; acid-base balance; ions; autonomic nervous system (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV
  • [D1C54A001448]
http://linked.open...i/riv/nazevZdroje
  • BIOL RHYTHM RES
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 45
http://linked.open...iv/tvurceVysledku
  • Švorc, Pavol
  • Marossy, A.
  • Bacova, I.
  • Jurasova, Z.
  • Novakova, M.
http://linked.open...ain/vavai/riv/wos
  • 000337580100015
issn
  • 0929-1016
number of pages
http://localhost/t...ganizacniJednotka
  • 17110
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