About: Plasma levels of vascular endothelial growth factor during and after radiotherapy in combination with celecoxib in patients with advanced head and neck cancer     Goto   Sponge   NotDistinct   Permalink

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  • Celebrex and radiotherapy in advanced head and neck cancer. This phase I dose-escalation study seeks to determine the phase II recommended dose of cyclooxygenase type 2 (COX-2) inhibitor in patients with locally advanced squamous cell head and neck (H&N) cancer, treated with accelerated radiotherapy. Anti-vasculogenic effect of this treatment on serum vascular endothelial growth factor (VEGF) is examined. Patients were irradiated with curative intent (72 Gy in 6 weeks). Celecoxib was administered throughout the radiotherapy course. Serum VEGF level were tested during radiotherapy and in follow-up. Tumor specimens were stained to quantify the COX-2 expression. Thirty-two patients completed the treatment. The dose of celecoxib was escalated (200, 400 and 800 mg bid, then de-escalated to 600 mg bid).
  • Celebrex and radiotherapy in advanced head and neck cancer. This phase I dose-escalation study seeks to determine the phase II recommended dose of cyclooxygenase type 2 (COX-2) inhibitor in patients with locally advanced squamous cell head and neck (H&N) cancer, treated with accelerated radiotherapy. Anti-vasculogenic effect of this treatment on serum vascular endothelial growth factor (VEGF) is examined. Patients were irradiated with curative intent (72 Gy in 6 weeks). Celecoxib was administered throughout the radiotherapy course. Serum VEGF level were tested during radiotherapy and in follow-up. Tumor specimens were stained to quantify the COX-2 expression. Thirty-two patients completed the treatment. The dose of celecoxib was escalated (200, 400 and 800 mg bid, then de-escalated to 600 mg bid). (en)
Title
  • Plasma levels of vascular endothelial growth factor during and after radiotherapy in combination with celecoxib in patients with advanced head and neck cancer
  • Plasma levels of vascular endothelial growth factor during and after radiotherapy in combination with celecoxib in patients with advanced head and neck cancer (en)
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  • Plasma levels of vascular endothelial growth factor during and after radiotherapy in combination with celecoxib in patients with advanced head and neck cancer
  • Plasma levels of vascular endothelial growth factor during and after radiotherapy in combination with celecoxib in patients with advanced head and neck cancer (en)
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  • RIV/61988987:17110/11:A1300X22!RIV13-MSM-17110___
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  • 220510
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  • RIV/61988987:17110/11:A1300X22
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  • SELECTIVE CYCLOOXYGENASE-2 INHIBITOR; SQUAMOUS-CELL CARCINOMA; I CLINICAL-TRIAL; PHASE-I; TUMOR ANGIOGENESIS; COX-2 INHIBITORS; ESOPHAGEAL-CANCER; LUNG-CANCER; EXPRESSION; RADIATION (en)
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  • 47
http://linked.open...iv/tvurceVysledku
  • Cvek, Jakub
  • Dušek, L.
  • Komínek, Pavel
  • Feltl, David
  • Kubeš, J.
  • Horáček, Jaroslav
  • Halámka, Magdalena
  • Závadová, E.
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  • 1368-8375
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  • 17110
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