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  • The clinical trials unanimously ascribe the increased risk of cardiac events to apneic episodes. The effect of reoxygenation after apneic episode on the development of ventricular arrhythmias have not been studied in detail as a function of the lightdark cycle (LD cycle). We aimed to study the effect of reoxygenation on ventricular arrhythmia threshold (VAT) with respect to the LD cycle. Experiments were undertaken in female Wistar rats. The results clearly demonstrate the pro-arrhythmogenic effect of apneic episode regardless of the LD cycle. During reoxygenation, anti-arrhythmogenic effect (increase in VAT) was observed in the dark (active) part in contrast to pro-arrhythmogenic effect (decrease in VAT), which was demostrated during the light (nonactive) part of the day. These data suggest that heart rhythm disorders attributed to apneic episode can be attenuated or amplified by subsequent reoxygenation dependent on synchronization to the LD cycle.
  • The clinical trials unanimously ascribe the increased risk of cardiac events to apneic episodes. The effect of reoxygenation after apneic episode on the development of ventricular arrhythmias have not been studied in detail as a function of the lightdark cycle (LD cycle). We aimed to study the effect of reoxygenation on ventricular arrhythmia threshold (VAT) with respect to the LD cycle. Experiments were undertaken in female Wistar rats. The results clearly demonstrate the pro-arrhythmogenic effect of apneic episode regardless of the LD cycle. During reoxygenation, anti-arrhythmogenic effect (increase in VAT) was observed in the dark (active) part in contrast to pro-arrhythmogenic effect (decrease in VAT), which was demostrated during the light (nonactive) part of the day. These data suggest that heart rhythm disorders attributed to apneic episode can be attenuated or amplified by subsequent reoxygenation dependent on synchronization to the LD cycle. (en)
Title
  • Chronobiological aspects of reoxygenation impact on the heart rhythm disorders in Wistar rat model
  • Chronobiological aspects of reoxygenation impact on the heart rhythm disorders in Wistar rat model (en)
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  • Chronobiological aspects of reoxygenation impact on the heart rhythm disorders in Wistar rat model
  • Chronobiological aspects of reoxygenation impact on the heart rhythm disorders in Wistar rat model (en)
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  • RIV/61988987:17110/11:A12013XB!RIV12-MSM-17110___
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  • V
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  • 15
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  • 190365
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  • RIV/61988987:17110/11:A12013XB
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  • chronobiology; heart rate; ventricular arrhythmia threshold; acid-base balance; apnoea; reoxygenation (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • IN - Indická republika
http://linked.open...ontrolniKodProRIV
  • [4C970FC8022A]
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  • Trendsin Comparative Biochem & Physiol
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  • Fulton, Benjamin L.
  • Švorc, Pavol
issn
  • 0972-4540
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http://localhost/t...ganizacniJednotka
  • 17110
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