About: Development of a treatment of pregnant women suffering from epilepsy in the region of Ostrava between the years 1991 and 2006

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The paper discusses long-term trends in the utilization of antiepileptic drugs during pregnancy and reports an analysis of their concentations at delivery. The reguest forms for routine therapeutic drug monitoring and concentrations of antiepileptic drugs at delivery collected between the years 1991-2006 were used as the data source. Monotherapy versus polytherapy, the utilization of individual antiepileptic drugs and combinations, and concentations were monitored in a group of 235 pregnancies within three 5-year periods. Monotherapy was used in 61 % in the years 1991-1995, in 68% in the years 1996-2000, and in 75 % in the years 2001-2006. During the 1 st period, the most frequently prescribed agents were phenytoin, carbamazepine and primidone, during the 2 nd period, carbamazepine, phenytoin, and valproic acid, and during the 3 rd period, carbamazepine, lamotrigine, and valproic acid. Concentations were mostly under the therapeutics range with an exception ofcarbamazepine and primidone. The paper discusses long-term trends in the utilization of antiepileptic drugs during pregnancy and reports an analysis of their concentations at delivery. The reguest forms for routine therapeutic drug monitoring and concentrations of antiepileptic drugs at delivery collected between the years 1991-2006 were used as the data source. Monotherapy versus polytherapy, the utilization of individual antiepileptic drugs and combinations, and concentations were monitored in a group of 235 pregnancies within three 5-year periods. Monotherapy was used in 61 % in the years 1991-1995, in 68% in the years 1996-2000, and in 75 % in the years 2001-2006. During the 1 st period, the most frequently prescribed agents were phenytoin, carbamazepine and primidone, during the 2 nd period, carbamazepine, phenytoin, and valproic acid, and during the 3 rd period, carbamazepine, lamotrigine, and valproic acid. Concentations were mostly under the therapeutics range with an exception ofcarbamazepine and primidone. (en)
Title	Development of a treatment of pregnant women suffering from epilepsy in the region of Ostrava between the years 1991 and 2006 Development of a treatment of pregnant women suffering from epilepsy in the region of Ostrava between the years 1991 and 2006 (en)
skos:prefLabel	Development of a treatment of pregnant women suffering from epilepsy in the region of Ostrava between the years 1991 and 2006 Development of a treatment of pregnant women suffering from epilepsy in the region of Ostrava between the years 1991 and 2006 (en)
skos:notation	RIV/61988987:17110/10:A1101094!RIV11-MSM-17110___
http://linked.open...avai/riv/aktivita	S
http://linked.open...avai/riv/aktivity	S
http://linked.open...iv/cisloPeriodika	59
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Kořístková, Blanka Grundmann, Milan Kacířová, Ivana
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ostravská univerzita v Ostravě / Lékařská fakulta
http://linked.open...dnocenehoVysledku	253918
http://linked.open...ai/riv/idVysledku	RIV/61988987:17110/10:A1101094
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	pregnancy; epilepsy; antiepileptic drugs; therapeutic drug monitoring (en)
http://linked.open.../riv/klicoveSlovo	pregnancy therapeutic drug monitoring antiepileptic drugs epilepsy
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[C42B69310D27]
http://linked.open...i/riv/nazevZdroje	Česká a slovenská farmacie
http://linked.open...in/vavai/riv/obor	FR
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	4
http://linked.open...iv/tvurceVysledku	Brozmanová, Hana Grundmann, Milan Kořístková, Blanka Kacířová, Ivana
issn	1210-7816
number of pages	7 (xsd:int)
http://localhost/t...ganizacniJednotka	17110
is http://linked.open...avai/riv/vysledek of	Development of a treatment of pregnant women suffering from epilepsy in the region of Ostrava between the years 1991 and 2006 Development of a treatment of pregnant women suffering from epilepsy in the region of Ostrava between the years 1991 and 2006 Development of a treatment of pregnant women suffering from epilepsy in the region of Ostrava between the years 1991 and 2006

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