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  • We followed up lamotrigine transport through the placenta and analyzed maternal and umibilical cord concentarions, its ratio and maternal latrigine clearance in monotherapy and in combinations.Materna and umbilical cord concentations were analyzed during delivery in a cohort of 63 women betweed 2001 and 2009. The request forms for routine therapeutic drug monitoring were used as the data source. Maternal concentarions were used for the estimation of apparent oral clearance and paired infant and maternal concentations for estimation of the infant (umibilical cord)/maternal serum concentation ratio. The lamotrigine infant/maternal serum concentration ratio ranged in monotherapy from 0,40 to 1,38 (median 0,91). The ratio in monotherapy showed a possible distribution to two subgroups. Concomitant administation of valproic acid significantly increasedboth maternal and infant lamotrigine concentrations and significantly decreased motrigine clearance by about 65%.
  • We followed up lamotrigine transport through the placenta and analyzed maternal and umibilical cord concentarions, its ratio and maternal latrigine clearance in monotherapy and in combinations.Materna and umbilical cord concentations were analyzed during delivery in a cohort of 63 women betweed 2001 and 2009. The request forms for routine therapeutic drug monitoring were used as the data source. Maternal concentarions were used for the estimation of apparent oral clearance and paired infant and maternal concentations for estimation of the infant (umibilical cord)/maternal serum concentation ratio. The lamotrigine infant/maternal serum concentration ratio ranged in monotherapy from 0,40 to 1,38 (median 0,91). The ratio in monotherapy showed a possible distribution to two subgroups. Concomitant administation of valproic acid significantly increasedboth maternal and infant lamotrigine concentrations and significantly decreased motrigine clearance by about 65%. (en)
Title
  • Serum levels of lamotrigine during delivery in mothers and their infants
  • Serum levels of lamotrigine during delivery in mothers and their infants (en)
skos:prefLabel
  • Serum levels of lamotrigine during delivery in mothers and their infants
  • Serum levels of lamotrigine during delivery in mothers and their infants (en)
skos:notation
  • RIV/61988987:17110/10:A110107I!RIV11-MSM-17110___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • S
http://linked.open...iv/cisloPeriodika
  • 7.8. 2010
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 287030
http://linked.open...ai/riv/idVysledku
  • RIV/61988987:17110/10:A110107I
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • lamotrigine; Therapeutic drug monitoring; epilepsy; delivery (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • NL - Nizozemsko
http://linked.open...ontrolniKodProRIV
  • [1B78DFAC7E5E]
http://linked.open...i/riv/nazevZdroje
  • EPILEPSIA
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 91
http://linked.open...iv/tvurceVysledku
  • Brozmanová, Hana
  • Grundmann, Milan
  • Kacířová, Ivana
issn
  • 0013-9580
number of pages
http://localhost/t...ganizacniJednotka
  • 17110
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