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| rdf:type
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| Description
| - Background: The aim of the work was to evaluate the possibility to estimate the level of cyclosporin A (CyA) metabolites as the difference of radioimmunoassay (RIA) non-specific and RIA specific methods. Methods: Blood samples of renal transplant patients were analyzed by three different methods: RIA specific method (CYCLO-Trac, DiaSorin, USA) (RIA(SP)), RIA non-specific method (Immunotech, Czech Republic) (RIA(NS)), and high performance liquid chromatography (HPLC) method. Conclusion: The combination of both the specific and non-specific methods for the determination of CyA presents an improved means for the TDM of CyA and CyA metabolites in renal transplant patients. Moreover, a combination of both methods can help to elucidate some unexpected events, such as the persistence of high cyclosporin blood levels. (C) 2001 Elsevier Science B.V. All rights reserved.
- Background: The aim of the work was to evaluate the possibility to estimate the level of cyclosporin A (CyA) metabolites as the difference of radioimmunoassay (RIA) non-specific and RIA specific methods. Methods: Blood samples of renal transplant patients were analyzed by three different methods: RIA specific method (CYCLO-Trac, DiaSorin, USA) (RIA(SP)), RIA non-specific method (Immunotech, Czech Republic) (RIA(NS)), and high performance liquid chromatography (HPLC) method. Conclusion: The combination of both the specific and non-specific methods for the determination of CyA presents an improved means for the TDM of CyA and CyA metabolites in renal transplant patients. Moreover, a combination of both methods can help to elucidate some unexpected events, such as the persistence of high cyclosporin blood levels. (C) 2001 Elsevier Science B.V. All rights reserved. (en)
- Cílem práce bylo zjistit možnost vlivu metabolitů cyklosporinu A na rozdíl výsledků specifické a nespecifické RIA metody. Krevní vzorky pacientů s transplantovanými metodami byly analyzovány 3 různými metodami: (CYCLO-Trac, DiaSorin, USA) (RIA(SP)), RIA nespecifická and RIA specifická methods a high performance liquid chromatography (HPLC) metoda. Kombinace spelcifické a nespecifické RIA metody při stanovení cyklosporinu A zlepšuje možnosti TDM cyklosporinu a může vysvětlit i některé neočekávané vysoké hladiny cyklosporinu A. (cs)
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| Title
| - Srovnání terapeutického monitorování cyklosporinu A a jeho metabolitů u pacientů s transplantovanými ledvinami při použití HPLC a RIA metod (cs)
- Evaluation and comparison of therapeutic monitoring of whole-blood levels of cyclosporin A and its metabolites in renal transplantation by HPLC and RIA methods
- Evaluation and comparison of therapeutic monitoring of whole-blood levels of cyclosporin A and its metabolites in renal transplantation by HPLC and RIA methods (en)
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| skos:prefLabel
| - Srovnání terapeutického monitorování cyklosporinu A a jeho metabolitů u pacientů s transplantovanými ledvinami při použití HPLC a RIA metod (cs)
- Evaluation and comparison of therapeutic monitoring of whole-blood levels of cyclosporin A and its metabolites in renal transplantation by HPLC and RIA methods
- Evaluation and comparison of therapeutic monitoring of whole-blood levels of cyclosporin A and its metabolites in renal transplantation by HPLC and RIA methods (en)
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| skos:notation
| - RIV/61988987:17110/01:A0900ANI!RIV09-MSM-17110___
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/61988987:17110/01:A0900ANI
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - cyclosporin A; metabolites; RIA; HPLC (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Brozmanová, Hana
- Grundmann, Milan
- Šafarčík, Kristian
- Jegorov, A.
- Bartoš, V.
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| http://linked.open...ain/vavai/riv/wos
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| issn
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| number of pages
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| http://localhost/t...ganizacniJednotka
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