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| Description
| - Inflammation is the natural body defense mechanism for the removal of injurious agents, necrosed cells and tissues from the body. This study was aimed to evaluate the anti-inflammatory and platelet aggregation effects of three medicinal plants of Pakistan. Methanolic extract of Garden pea inhibited arachidonic acid (AA)-induced platelet aggregation (IC50 = 35 μg/mL) and platelet activating factor (PAF)-induced platelet aggregation (IC50 = 38 μg/mL) in a dose dependent fashion. Methanolic extract of Desi chickpea inhibited arachidonic acid (AA) induced platelet aggregation (IC50 value = AA = 46 μg/mL) in dose dependent fashion while was found not active against PAF-induced platelet aggregation. Methanolic extract of Kabuli chickpea was found not active against both arachidonic acid (AA)-induced platelet aggregation and PAF-induced platelet aggregation. The best potential to inhibit in vitro COX-2 activity showed garden pea (Pisum sativum; the synthesis of PGE2 reduced by 92% in comparison with untreated control wells) followed by Desi chickpea (Cicer arietinum var; 87% inhibition) and Kabuli chickpea extracts (Cicer arietinum var; 65% inhibition). All extracts were tested at concentration 20 μg/mL. in COX-2 assay.The results indicate that if the same were happening in vivo, Garden pea, Desi chickpea and Kabuli chickpea could be useful as natural antithrombotic anti-inflammatory materials.
- Inflammation is the natural body defense mechanism for the removal of injurious agents, necrosed cells and tissues from the body. This study was aimed to evaluate the anti-inflammatory and platelet aggregation effects of three medicinal plants of Pakistan. Methanolic extract of Garden pea inhibited arachidonic acid (AA)-induced platelet aggregation (IC50 = 35 μg/mL) and platelet activating factor (PAF)-induced platelet aggregation (IC50 = 38 μg/mL) in a dose dependent fashion. Methanolic extract of Desi chickpea inhibited arachidonic acid (AA) induced platelet aggregation (IC50 value = AA = 46 μg/mL) in dose dependent fashion while was found not active against PAF-induced platelet aggregation. Methanolic extract of Kabuli chickpea was found not active against both arachidonic acid (AA)-induced platelet aggregation and PAF-induced platelet aggregation. The best potential to inhibit in vitro COX-2 activity showed garden pea (Pisum sativum; the synthesis of PGE2 reduced by 92% in comparison with untreated control wells) followed by Desi chickpea (Cicer arietinum var; 87% inhibition) and Kabuli chickpea extracts (Cicer arietinum var; 65% inhibition). All extracts were tested at concentration 20 μg/mL. in COX-2 assay.The results indicate that if the same were happening in vivo, Garden pea, Desi chickpea and Kabuli chickpea could be useful as natural antithrombotic anti-inflammatory materials. (en)
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| Title
| - PLATELET AGGREGATION AND ANTI-INFLAMMATORY EFFECTS OF GARDEN PEA, DESI CHICKPEA AND KABULI CHICKPEA
- PLATELET AGGREGATION AND ANTI-INFLAMMATORY EFFECTS OF GARDEN PEA, DESI CHICKPEA AND KABULI CHICKPEA (en)
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| skos:prefLabel
| - PLATELET AGGREGATION AND ANTI-INFLAMMATORY EFFECTS OF GARDEN PEA, DESI CHICKPEA AND KABULI CHICKPEA
- PLATELET AGGREGATION AND ANTI-INFLAMMATORY EFFECTS OF GARDEN PEA, DESI CHICKPEA AND KABULI CHICKPEA (en)
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| skos:notation
| - RIV/61389030:_____/12:00380748!RIV13-AV0-61389030
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| http://linked.open...avai/predkladatel
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/61389030:_____/12:00380748
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - platelet aggregation; Garden pea; Desi chickpea (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
| - Acta Poloniae Pharmaceutica: drug research
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Landa, Přemysl
- Kutil, Zsófia
- Ahmad, S.
- AHMED, S.
- ALI KHAN, B.
- QAYUM, M.
- ZIA-UL-HAQ, M.
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| http://linked.open...ain/vavai/riv/wos
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| http://linked.open...n/vavai/riv/zamer
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| issn
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| number of pages
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| is http://linked.open...avai/riv/vysledek
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