About: Molecular structure of phospholipase D and regulatory mechanisms of its activity in plant and animal cells

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Phospholipase D (PLD) catalyzes hydrolysis of phospholipids with production of phosphatidic acid, which often acts as secondary messenger of transduction of intracellular signals. This review summarizes data of leading laboratories on specific features of organization and regulation of PLD activity in plant and animal cells. The main structural domains of PLD (C2, PX, PH), the active site, and other functionally important parts of the enzyme are discussed. Regulatory mechanisms of PLD activity are characterized in detail. Studies associated with molecular design, analysis, and synthesis of new nontoxic substances capable of inhibiting different PLD isoenzymes in vivo are shown to be promising for biotechnology and medicine. Phospholipase D (PLD) catalyzes hydrolysis of phospholipids with production of phosphatidic acid, which often acts as secondary messenger of transduction of intracellular signals. This review summarizes data of leading laboratories on specific features of organization and regulation of PLD activity in plant and animal cells. The main structural domains of PLD (C2, PX, PH), the active site, and other functionally important parts of the enzyme are discussed. Regulatory mechanisms of PLD activity are characterized in detail. Studies associated with molecular design, analysis, and synthesis of new nontoxic substances capable of inhibiting different PLD isoenzymes in vivo are shown to be promising for biotechnology and medicine. (en)
Title	Molecular structure of phospholipase D and regulatory mechanisms of its activity in plant and animal cells Molecular structure of phospholipase D and regulatory mechanisms of its activity in plant and animal cells (en)
skos:prefLabel	Molecular structure of phospholipase D and regulatory mechanisms of its activity in plant and animal cells Molecular structure of phospholipase D and regulatory mechanisms of its activity in plant and animal cells (en)
skos:notation	RIV/61389030:_____/12:00380581!RIV13-AV0-61389030
http://linked.open...avai/predkladatel	Ústav experimentální botaniky AV ČR, v.v.i.
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GAP501/11/1654), Z(AV0Z50380511)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Martinec, Jan
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav experimentální botaniky AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	151560
http://linked.open...ai/riv/idVysledku	RIV/61389030:_____/12:00380581
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	phospholipase D; domains; calcium (en)
http://linked.open.../riv/klicoveSlovo	calcium domains phospholipase D
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[EFC2AF88F9BF]
http://linked.open...i/riv/nazevZdroje	Biochemistry-Moscow
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	Phospholipid signaling and interaction with microtubule/actin cytoskeleton in biotic stress response of Arabidopsis thaliana
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	77
http://linked.open...iv/tvurceVysledku	Martinec, Jan Kolesnikov, Y. S. Kravets, V. S. Kretynin, S. V. Nokhrina, K. P. Romanov, G. A. Volotovski, I. D.
http://linked.open...ain/vavai/riv/wos	000299897200001
http://linked.open...n/vavai/riv/zamer	Mechanismy regulace růstu a vývoje rostlin na úrovni buněk, orgánů a celých organismů: fyziologické, genetické a molekulárně biologické základy
issn	0006-2979
number of pages	14 (xsd:int)
http://bibframe.org/vocab/doi	10.1134/S0006297912010014
is http://linked.open...avai/riv/vysledek of	Molecular structure of phospholipase D and regulatory mechanisms of its activity in plant and animal cells

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