About: Succinobucol’s New Coat - Conjugation with Steroids to Alter Its Drug Effect and Bioavailability

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Synthesis, detailed structural characterization (X-ray, NMR, MS, IR, elemental analysis), and studies of toxicity, antioxidant activity and bioavailability of unique potent anti-atherosclerotic succinobucol-steroid conjugates are reported. The conjugates consist of, on one side, the therapeutically important drug succinobucol ([4-{2,6-di-tert-butyl-4-[(1-{[3-tert-butyl-4-hydroxy-5-(propan-2-yl)phenyl]sulfanyl}ethyl)sulfanyl]phenoxy}-4-oxo-butanoic acid]) possessing an antioxidant and anti-inflammatory activity, and on the other side, plant stanol/sterols (stigmastanol, β-sitosterol and stigmasterol) possessing an ability to lower the blood cholesterol level. A cholesterol-succinobucol prodrug was also prepared in order to enhance the absorption of succinobucol through the intestinal membrane into the organism and to target the drug into the place of lipid metabolism—The enterohepatic circulation system. Synthesis, detailed structural characterization (X-ray, NMR, MS, IR, elemental analysis), and studies of toxicity, antioxidant activity and bioavailability of unique potent anti-atherosclerotic succinobucol-steroid conjugates are reported. The conjugates consist of, on one side, the therapeutically important drug succinobucol ([4-{2,6-di-tert-butyl-4-[(1-{[3-tert-butyl-4-hydroxy-5-(propan-2-yl)phenyl]sulfanyl}ethyl)sulfanyl]phenoxy}-4-oxo-butanoic acid]) possessing an antioxidant and anti-inflammatory activity, and on the other side, plant stanol/sterols (stigmastanol, β-sitosterol and stigmasterol) possessing an ability to lower the blood cholesterol level. A cholesterol-succinobucol prodrug was also prepared in order to enhance the absorption of succinobucol through the intestinal membrane into the organism and to target the drug into the place of lipid metabolism—The enterohepatic circulation system. (en)
Title	Succinobucol’s New Coat - Conjugation with Steroids to Alter Its Drug Effect and Bioavailability Succinobucol’s New Coat - Conjugation with Steroids to Alter Its Drug Effect and Bioavailability (en)
skos:prefLabel	Succinobucol’s New Coat - Conjugation with Steroids to Alter Its Drug Effect and Bioavailability Succinobucol’s New Coat - Conjugation with Steroids to Alter Its Drug Effect and Bioavailability (en)
skos:notation	RIV/61389030:_____/11:00368252!RIV12-AV0-61389030
http://linked.open...avai/predkladatel	Ústav experimentální botaniky AV ČR, v.v.i.
http://linked.open...avai/riv/aktivita	I P Z
http://linked.open...avai/riv/aktivity	I, P(2B06024), P(ED0030/01/01), P(GA203/09/2037), P(OC10001), Z(AV0Z40550506), Z(AV0Z50380511)
http://linked.open...iv/cisloPeriodika	11
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Buřičová, Lucie Wimmer, Zdeněk Jurček, Ondřej Wimmerová, Martina
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav experimentální botaniky AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	233336
http://linked.open...ai/riv/idVysledku	RIV/61389030:_____/11:00368252
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	succinobucol; phytosterol; atherosclerosis (en)
http://linked.open.../riv/klicoveSlovo	phytosterol succinobucol atherosclerosis
http://linked.open...odStatuVydavatele	CH - Švýcarská konfederace
http://linked.open...ontrolniKodProRIV	[2F6CEB8A8DD5]
http://linked.open...i/riv/nazevZdroje	Molecules
http://linked.open...in/vavai/riv/obor	CC
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	10 (xsd:int)
http://linked.open...vavai/riv/projekt	Supramolecular materials based on natural phytosterols for application in biology Multiscale modeling of endohedral fullerenes. Molecular dynamics, electronic structure, and molecular properties Biomedicine for regional development and human resources Supramolecular systems in chemical biology
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	16
http://linked.open...iv/tvurceVysledku	Buřičová, Lucie Drašar, P. Jurček, Ondřej Kolehmainen, E. T. Wimmer, Zdeněk Ulrichová, J. Horníček, Jan Galandáková, A. Ikonen, S. Wimmerová, Martina
http://linked.open...ain/vavai/riv/wos	000297697200038
http://linked.open...n/vavai/riv/zamer	Regulace biologických procesů: Chemické modulátory vybraných systémů významných pro medicínu a zemědělství Mechanismy regulace růstu a vývoje rostlin na úrovni buněk, orgánů a celých organismů: fyziologické, genetické a molekulárně biologické základy
issn	1420-3049
number of pages	17 (xsd:int)
http://bibframe.org/vocab/doi	10.3390/molecules16119404
is http://linked.open...avai/riv/vysledek of	Succinobucol’s New Coat - Conjugation with Steroids to Alter Its Drug Effect and Bioavailability Succinobucol’s New Coat - Conjugation with Steroids to Alter Its Drug Effect and Bioavailability

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