About: In vitro anti-inflammatory activity of carvacrol: Inhibitory effect on COX-2 catalyzed prostaglandin E-2 biosynthesis

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Possible anti-inflammatory effect of carvacrol was evaluated by in vitro cyclooxygenase-2 (COX-2) assay. Carvacrol inhibited production of prostaglandin E-2 catalysed by COX-2 with an IC50 value of 0.8 mu M what is practically the same concentration as the IC50 obtained for the standard inhibitors indomethacin and NS-398 with values of 0.7 mu M and 0.8 mu M, respectively. The COX-1 was inhibited approximately at the same rate (IC50 of 0.7 mu M for carvacrol), which suggests non-selective inhibition of both enzyme isoforms. The results of the study demonstrate possible anti-inflammatory potential of this compound due to the inhibition of inducible COX-2 isoform. Possible anti-inflammatory effect of carvacrol was evaluated by in vitro cyclooxygenase-2 (COX-2) assay. Carvacrol inhibited production of prostaglandin E-2 catalysed by COX-2 with an IC50 value of 0.8 mu M what is practically the same concentration as the IC50 obtained for the standard inhibitors indomethacin and NS-398 with values of 0.7 mu M and 0.8 mu M, respectively. The COX-1 was inhibited approximately at the same rate (IC50 of 0.7 mu M for carvacrol), which suggests non-selective inhibition of both enzyme isoforms. The results of the study demonstrate possible anti-inflammatory potential of this compound due to the inhibition of inducible COX-2 isoform. (en)
Title	In vitro anti-inflammatory activity of carvacrol: Inhibitory effect on COX-2 catalyzed prostaglandin E-2 biosynthesis In vitro anti-inflammatory activity of carvacrol: Inhibitory effect on COX-2 catalyzed prostaglandin E-2 biosynthesis (en)
skos:prefLabel	In vitro anti-inflammatory activity of carvacrol: Inhibitory effect on COX-2 catalyzed prostaglandin E-2 biosynthesis In vitro anti-inflammatory activity of carvacrol: Inhibitory effect on COX-2 catalyzed prostaglandin E-2 biosynthesis (en)
skos:notation	RIV/61389030:_____/09:00335925!RIV10-MSM-61389030
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(1P04OC926.001), P(GA525/08/1179), Z(AV0Z50380511)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Vaněk, Tomáš Landa, Přemysl Maršík, Petr Přibylová, Marie
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav experimentální botaniky AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	318913
http://linked.open...ai/riv/idVysledku	RIV/61389030:_____/09:00335925
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Carvacrol; Cyclooxygenase; Prostaglandin (en)
http://linked.open.../riv/klicoveSlovo	Cyclooxygenase Prostaglandin Carvacrol
http://linked.open...odStatuVydavatele	KR - Korejská republika
http://linked.open...ontrolniKodProRIV	[3B2150C40963]
http://linked.open...i/riv/nazevZdroje	Archives of Pharmacal Research
http://linked.open...in/vavai/riv/obor	GM
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Utilization of molecular techniques for study of the biological activity of plant derived compounds Determination of biological activity and chemical composition of selected tropical and subtropical Ranunculaceae species
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	32
http://linked.open...iv/tvurceVysledku	Kokoška, L. Maršík, Petr Vaněk, Tomáš Landa, Přemysl Přibylová, Marie
http://linked.open...ain/vavai/riv/wos	000262851700010
http://linked.open...n/vavai/riv/zamer	Mechanismy regulace růstu a vývoje rostlin na úrovni buněk, orgánů a celých organismů: fyziologické, genetické a molekulárně biologické základy
issn	0253-6269
number of pages	4 (xsd:int)
is http://linked.open...avai/riv/vysledek of	In vitro anti-inflammatory activity of carvacrol: Inhibitory effect on COX-2 catalyzed prostaglandin E-2 biosynthesis In vitro anti-inflammatory activity of carvacrol: Inhibitory effect on COX-2 catalyzed prostaglandin E-2 biosynthesis In vitro anti-inflammatory activity of carvacrol: Inhibitory effect on COX-2 catalyzed prostaglandin E-2 biosynthesis In vitro anti-inflammatory activity of carvacrol: Inhibitory effect on COX-2 catalyzed prostaglandin E-2 biosynthesis

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