About: Hierarchical antifouling brushes for biosensing applications

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	In this report, hierarchically structured diblock copolymer brushes are shown as an effective alternative to limit the increase in fouling caused by the activation of functional groups for the attachment of biorecognition elements. The growth of antifouling diblock copolymer brushes containing hydroxyl- and carboxy-functional top blocks was enabled by the utilization of surface-initiated atom transfer radical polymerization. The fouling from blood plasma is minimized, which is an essential property for the applications of these surfaces in label-free affinity biosensors for medical diagnostics and other fields that involve complex biological matrices. Furthermore, the increase in fouling associated with the activation of functional groups was significantly lowered. The use of a top block consisting of poly(carboxybetaine acrylamide) displays improved performance relative to a hydroxyl-bearing polymer after activation. A biosensor able to detect a targeted protein spiked in undiluted blood plasma is presented as a proof of concept. In this report, hierarchically structured diblock copolymer brushes are shown as an effective alternative to limit the increase in fouling caused by the activation of functional groups for the attachment of biorecognition elements. The growth of antifouling diblock copolymer brushes containing hydroxyl- and carboxy-functional top blocks was enabled by the utilization of surface-initiated atom transfer radical polymerization. The fouling from blood plasma is minimized, which is an essential property for the applications of these surfaces in label-free affinity biosensors for medical diagnostics and other fields that involve complex biological matrices. Furthermore, the increase in fouling associated with the activation of functional groups was significantly lowered. The use of a top block consisting of poly(carboxybetaine acrylamide) displays improved performance relative to a hydroxyl-bearing polymer after activation. A biosensor able to detect a targeted protein spiked in undiluted blood plasma is presented as a proof of concept. (en)
Title	Hierarchical antifouling brushes for biosensing applications Hierarchical antifouling brushes for biosensing applications (en)
skos:prefLabel	Hierarchical antifouling brushes for biosensing applications Hierarchical antifouling brushes for biosensing applications (en)
skos:notation	RIV/61389013:_____/14:00429950!RIV15-GA0-61389013
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(ED1.1.00/02.0109), P(EE2.3.30.0029), P(GAP205/12/1702)
http://linked.open...iv/cisloPeriodika	31 October
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Brynda, Eduard Riedel, Tomáš Rodriguez-Emmenegger, Cesar de los Santos Pereira, Andres
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav makromolekulární chemie AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	19032
http://linked.open...ai/riv/idVysledku	RIV/61389013:_____/14:00429950
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	hierarchically structured brushes; affinity biosensors; fouling (en)
http://linked.open.../riv/klicoveSlovo	hierarchically structured brushes fouling affinity biosensors
http://linked.open...odStatuVydavatele	CH - Švýcarská konfederace
http://linked.open...ontrolniKodProRIV	[003799B85285]
http://linked.open...i/riv/nazevZdroje	Sensors and Actuators B - Chemical
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Biotechnology and Biomedicine Centre of the Academy of Sciences and Charles University BIOPOL: BIOpolymer POstdoc Laboratory and educative center Interaction of complex biological fluids with synthetic surfaces resistant to protein adsorption
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	202
http://linked.open...iv/tvurceVysledku	Brynda, Eduard Riedel, Tomáš Rodriguez-Emmenegger, Cesar de los Santos Pereira, Andres
http://linked.open...ain/vavai/riv/wos	000339994900168
issn	0925-4005
number of pages	9 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.snb.2014.06.075

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