About: Enhanced tumor uptake and penetration of virotherapy using polymer stealthing and focused ultrasound

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About: Enhanced tumor uptake and penetration of virotherapy using polymer stealthing and focused ultrasound Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Oncolytic viruses are among the most powerful and selective cancer therapeutics under development and are showing robust activity in clinical trials, particularly when administered directly into tumor nodules. However, their intravenous administration to treat metastatic disease has been stymied by unfavorable pharmacokinetics and inefficient accumulation in and penetration through tumors. Combining drug stealthing and ultrasound-induced cavitation may ultimately enhance the efficacy of a range of powerful therapeutics, thereby improving the treatment of metastatic cancer. Oncolytic viruses are among the most powerful and selective cancer therapeutics under development and are showing robust activity in clinical trials, particularly when administered directly into tumor nodules. However, their intravenous administration to treat metastatic disease has been stymied by unfavorable pharmacokinetics and inefficient accumulation in and penetration through tumors. Combining drug stealthing and ultrasound-induced cavitation may ultimately enhance the efficacy of a range of powerful therapeutics, thereby improving the treatment of metastatic cancer. (en)
Title	Enhanced tumor uptake and penetration of virotherapy using polymer stealthing and focused ultrasound Enhanced tumor uptake and penetration of virotherapy using polymer stealthing and focused ultrasound (en)
skos:prefLabel	Enhanced tumor uptake and penetration of virotherapy using polymer stealthing and focused ultrasound Enhanced tumor uptake and penetration of virotherapy using polymer stealthing and focused ultrasound (en)
skos:notation	RIV/61389013:_____/13:00399052!RIV14-AV0-61389013
http://linked.open...avai/predkladatel	Ústav makromolekulární chemie AV ČR, v. v. i.
http://linked.open...avai/riv/aktivita	I
http://linked.open...avai/riv/aktivity	I
http://linked.open...iv/cisloPeriodika	22
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Ulbrich, Karel Šubr, Vladimír Kostka, Libor
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav makromolekulární chemie AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	72937
http://linked.open...ai/riv/idVysledku	RIV/61389013:_____/13:00399052
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	cancer; intravenous; adenovirus (en)
http://linked.open.../riv/klicoveSlovo	cancer adenovirus intravenous
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[28CE283E0FB1]
http://linked.open...i/riv/nazevZdroje	JNCI-Journal of the National Cancer Institute
http://linked.open...in/vavai/riv/obor	CD
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	105
http://linked.open...iv/tvurceVysledku	Ulbrich, Karel Seymour, L. W. Šubr, Vladimír Choi, J. Kostka, Libor Carlisle, R. Bazan-Peregrino, M. Coussios, C. C. Laga, R.
http://linked.open...ain/vavai/riv/wos	000327539000007
issn	0027-8874
number of pages	10 (xsd:int)
http://bibframe.org/vocab/doi	10.1093/jnci/djt305

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