About: Characterization of solid polymer dispersions of active pharmaceutical ingredients by 19F MAS NMR and factor analysis

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	In this contribution the ability of 19F MAS NMR spectroscopy to probe structural variability of poorly water-soluble drugs formulated as solid dispersions in polymer matrices is discussed. The application potentiality of the proposed approach is demonstrated on a moderately sized active pharmaceutical ingredient (API, Atorvastatin) exhibiting extensive polymorphism. In this respect, a range of model systems with the API incorporated in the matrix of polvinylpyrrolidone (PVP) was prepared. In this contribution the ability of 19F MAS NMR spectroscopy to probe structural variability of poorly water-soluble drugs formulated as solid dispersions in polymer matrices is discussed. The application potentiality of the proposed approach is demonstrated on a moderately sized active pharmaceutical ingredient (API, Atorvastatin) exhibiting extensive polymorphism. In this respect, a range of model systems with the API incorporated in the matrix of polvinylpyrrolidone (PVP) was prepared. (en)
Title	Characterization of solid polymer dispersions of active pharmaceutical ingredients by 19F MAS NMR and factor analysis Characterization of solid polymer dispersions of active pharmaceutical ingredients by 19F MAS NMR and factor analysis (en)
skos:prefLabel	Characterization of solid polymer dispersions of active pharmaceutical ingredients by 19F MAS NMR and factor analysis Characterization of solid polymer dispersions of active pharmaceutical ingredients by 19F MAS NMR and factor analysis (en)
skos:notation	RIV/61389013:_____/13:00383512!RIV13-AV0-61389013
http://linked.open...avai/predkladatel	Ústav makromolekulární chemie AV ČR, v. v. i.
http://linked.open...avai/riv/aktivita	I P Z
http://linked.open...avai/riv/aktivity	I, P(2B08021), P(GPP106/11/P426), Z(AV0Z40500505)
http://linked.open...iv/cisloPeriodika	1 January
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Policianová, Olivia Urbanová, Martina Šeděnková, Ivana Brus, Jiří Kobera, Libor
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav makromolekulární chemie AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	65100
http://linked.open...ai/riv/idVysledku	RIV/61389013:_____/13:00383512
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	solid-state NMR; factor analysis; 19F MAS NMR (en)
http://linked.open.../riv/klicoveSlovo	factor analysis solid-state NMR 19F MAS NMR
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[4DF8D81105F2]
http://linked.open...i/riv/nazevZdroje	Spectrochimica Acta Part A-Molecular and Biomolecular Spectroscopy
http://linked.open...in/vavai/riv/obor	FR
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Enhancement of bioavailability of insoluble pharmaceutical substances by the action of polymeric matrix NMR crystallography of active pharmaceuticals ingredients for industrial applications
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	100
http://linked.open...iv/tvurceVysledku	Urbanová, Martina Šeděnková, Ivana Brus, Jiří Kobera, Libor Policianová, Olivia
http://linked.open...ain/vavai/riv/wos	000312181800009
http://linked.open...n/vavai/riv/zamer	Progresivní makromolekulární materiály a supramolekulární systémy: syntéza a studium vlastností, jevů a možností využití pro speciální aplikace a moderní technologie
issn	1386-1425
number of pages	8 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.saa.2012.02.057

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