About: Hydrolytically degradable polymer micelles for anticancer drug delivery to solid tumors

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Various biodegradable micellar polymer drug carriers based on N -(2-hydroxypropyl)methacrylamide copolymers and their conjugates with doxorubicin are synthesized. The conjugates are designed to treat solid tumors and subsequently to allow carrier elimination from the body. All copolymers self-assemble in aqueous solution into supramolecular structures with highly hydrophobic cholesterol derivatives in the core and doxorubicin located in the hydrophilic shell. The drug is released quickly from the micelles incubated at pH = 5.0 (modelling the endosomes of tumor cells). Slower release of cholesterol derivatives leading to disintegration of the micelles is observed. Various biodegradable micellar polymer drug carriers based on N -(2-hydroxypropyl)methacrylamide copolymers and their conjugates with doxorubicin are synthesized. The conjugates are designed to treat solid tumors and subsequently to allow carrier elimination from the body. All copolymers self-assemble in aqueous solution into supramolecular structures with highly hydrophobic cholesterol derivatives in the core and doxorubicin located in the hydrophilic shell. The drug is released quickly from the micelles incubated at pH = 5.0 (modelling the endosomes of tumor cells). Slower release of cholesterol derivatives leading to disintegration of the micelles is observed. (en)
Title	Hydrolytically degradable polymer micelles for anticancer drug delivery to solid tumors Hydrolytically degradable polymer micelles for anticancer drug delivery to solid tumors (en)
skos:prefLabel	Hydrolytically degradable polymer micelles for anticancer drug delivery to solid tumors Hydrolytically degradable polymer micelles for anticancer drug delivery to solid tumors (en)
skos:notation	RIV/61389013:_____/12:00376432!RIV13-AV0-61389013
http://linked.open...avai/predkladatel	Ústav makromolekulární chemie AV ČR, v. v. i.
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GAP301/11/0325), P(IAAX00500803), Z(AV0Z40500505)
http://linked.open...iv/cisloPeriodika	8
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Ulbrich, Karel Chytil, Petr Etrych, Tomáš Kostka, Libor
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav makromolekulární chemie AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	140058
http://linked.open...ai/riv/idVysledku	RIV/61389013:_____/12:00376432
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	HPMA copolymers; drug delivery systems; doxorubicin (en)
http://linked.open.../riv/klicoveSlovo	doxorubicin HPMA copolymers drug delivery systems
http://linked.open...odStatuVydavatele	DE - Spolková republika Německo
http://linked.open...ontrolniKodProRIV	[CC3A55CD05B4]
http://linked.open...i/riv/nazevZdroje	Macromolecular Chemistry and Physics
http://linked.open...in/vavai/riv/obor	EC
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Depletion of T regulatory cells without need of anti-CD25 mAb for effective chemoimmunotherapy by HPMA-based polymeric drugs and IL-2 immunocomplexes Multifunctional Polymer Systems with Cytostatic and Immunomobilizing Activities
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	213
http://linked.open...iv/tvurceVysledku	Chytil, Petr Etrych, Tomáš Ulbrich, Karel Kostka, Libor
http://linked.open...ain/vavai/riv/wos	000302912300008
http://linked.open...n/vavai/riv/zamer	Progresivní makromolekulární materiály a supramolekulární systémy: syntéza a studium vlastností, jevů a možností využití pro speciální aplikace a moderní technologie
issn	1022-1352
number of pages	10 (xsd:int)
http://bibframe.org/vocab/doi	10.1002/macp.201100632
is http://linked.open...avai/riv/vysledek of	Hydrolytically degradable polymer micelles for anticancer drug delivery to solid tumors

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