About: Hydrazone-based hydrogel hydrolytically degradable in acidic environment

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	We describe the synthesis of new crosslinker N-{3-[2-(4-{2-[3-(methacryloylamino) propanoyl] hydrazono}cyclohexyliden)hydrazino]-3-oxopropyl}-2-methylacrylamide, which is stable at physiological pH, but is hydrolytically cleaved in acidic pH. Study of acid hydrolysis showed that the crosslinker is hydrolyzed into two N-(3-hydrazino-3-oxopropyl)-2-methylacrylamide molecules and one 1,4-cyclohexanedione molecule. Hydrogels based on poly[N-(2-hydroxypropyl)methacrylamide] crosslinked with this crosslinker were prepared and their degradation rate was studied as a function of pH (in the range of pH 1.5–7.4). The hydrogel is cleaved within 8–27 days at pH between 1.5 and 6 and is stable at pH 7.4 making it promising for the construction of oesophageal stents. We describe the synthesis of new crosslinker N-{3-[2-(4-{2-[3-(methacryloylamino) propanoyl] hydrazono}cyclohexyliden)hydrazino]-3-oxopropyl}-2-methylacrylamide, which is stable at physiological pH, but is hydrolytically cleaved in acidic pH. Study of acid hydrolysis showed that the crosslinker is hydrolyzed into two N-(3-hydrazino-3-oxopropyl)-2-methylacrylamide molecules and one 1,4-cyclohexanedione molecule. Hydrogels based on poly[N-(2-hydroxypropyl)methacrylamide] crosslinked with this crosslinker were prepared and their degradation rate was studied as a function of pH (in the range of pH 1.5–7.4). The hydrogel is cleaved within 8–27 days at pH between 1.5 and 6 and is stable at pH 7.4 making it promising for the construction of oesophageal stents. (en)
Title	Hydrazone-based hydrogel hydrolytically degradable in acidic environment Hydrazone-based hydrogel hydrolytically degradable in acidic environment (en)
skos:prefLabel	Hydrazone-based hydrogel hydrolytically degradable in acidic environment Hydrazone-based hydrogel hydrolytically degradable in acidic environment (en)
skos:notation	RIV/61389013:_____/11:00359454!RIV12-AV0-61389013
http://linked.open...avai/predkladatel	Ústav makromolekulární chemie AV ČR, v. v. i.
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(1M0538), P(GAP108/10/1560), P(GPP207/10/P054), Z(AV0Z40500505)
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Hrubý, Martin Michálek, Jiří Přádný, Martin Vetrík, Miroslav
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav makromolekulární chemie AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	203096
http://linked.open...ai/riv/idVysledku	RIV/61389013:_____/11:00359454
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	polymer; hydrogel; hydrazone bond (en)
http://linked.open.../riv/klicoveSlovo	polymer hydrogel hydrazone bond
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[073909C16794]
http://linked.open...i/riv/nazevZdroje	Polymer Degradation and Stability
http://linked.open...in/vavai/riv/obor	CD
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Center for Cell Therapy and Tissue Repair New generation of reductively biodegradable functionalized macroporous scaffolds for neural tissue engineering Polymeric micelles with metal ion – assembled core
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	96
http://linked.open...iv/tvurceVysledku	Hrubý, Martin Michálek, Jiří Přádný, Martin Vetrík, Miroslav
http://linked.open...ain/vavai/riv/wos	000290078200004
http://linked.open...n/vavai/riv/zamer	Progresivní makromolekulární materiály a supramolekulární systémy: syntéza a studium vlastností, jevů a možností využití pro speciální aplikace a moderní technologie
issn	0141-3910
number of pages	4 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.polymdegradstab.2011.02.020
is http://linked.open...avai/riv/vysledek of	Hydrazone-based hydrogel hydrolytically degradable in acidic environment Hydrazone-based hydrogel hydrolytically degradable in acidic environment

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