About: Enzymatic degradation of the hydrogels based on synthetic poly(.alpha.-amino acid)s

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About: Enzymatic degradation of the hydrogels based on synthetic poly(.alpha.-amino acid)s Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Biodegradable hydrogels are studied as potential scaffolds for soft tissue regeneration. In this work biodegradable hydrogels were prepared from synthetic poly (a-amino acid)s, poly(AA)s. The covalently crosslinked gels were formed by radical copolymerization of methacryloylated poly(AA)s, e.g. poly[N5-(2-hydroxy-ethyl)-L-Glu- ran-L-Ala-ran-N6-methacryloyl-L-Lys], as a multifunctional macromer with a low-molecular-weight methacrylic monofunctional monomer, e.g. HEMA. Due to their polypeptide backbone, synthetic poly(AA)s are cleavable in biological environment by enzyme-catalyzed hydrolysis. The feasibility of enzymatic degradation of poly(AA)s alone and the hydrogels made from them was studied using elastase, a matrix proteinase involved in tissue healing processes, as a model enzyme. Specificity of elastase for cleavage of polypeptide chains behind the L-Ala residues was reflected in faster degradation of L-Ala-containing copolymers as well as of hydrogels composed of them. Biodegradable hydrogels are studied as potential scaffolds for soft tissue regeneration. In this work biodegradable hydrogels were prepared from synthetic poly (a-amino acid)s, poly(AA)s. The covalently crosslinked gels were formed by radical copolymerization of methacryloylated poly(AA)s, e.g. poly[N5-(2-hydroxy-ethyl)-L-Glu- ran-L-Ala-ran-N6-methacryloyl-L-Lys], as a multifunctional macromer with a low-molecular-weight methacrylic monofunctional monomer, e.g. HEMA. Due to their polypeptide backbone, synthetic poly(AA)s are cleavable in biological environment by enzyme-catalyzed hydrolysis. The feasibility of enzymatic degradation of poly(AA)s alone and the hydrogels made from them was studied using elastase, a matrix proteinase involved in tissue healing processes, as a model enzyme. Specificity of elastase for cleavage of polypeptide chains behind the L-Ala residues was reflected in faster degradation of L-Ala-containing copolymers as well as of hydrogels composed of them. (en)
Title	Enzymatic degradation of the hydrogels based on synthetic poly(.alpha.-amino acid)s Enzymatic degradation of the hydrogels based on synthetic poly(.alpha.-amino acid)s (en)
skos:prefLabel	Enzymatic degradation of the hydrogels based on synthetic poly(.alpha.-amino acid)s Enzymatic degradation of the hydrogels based on synthetic poly(.alpha.-amino acid)s (en)
skos:notation	RIV/61389013:_____/11:00359220!RIV12-AV0-61389013
http://linked.open...avai/predkladatel	Ústav makromolekulární chemie AV ČR, v. v. i.
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(1M0538), P(GP203/04/P124), P(KJB400500801), Z(AV0Z40500505)
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Studenovská, Hana Sedlačík, Tomáš Rypáček, František
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav makromolekulární chemie AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	197795
http://linked.open...ai/riv/idVysledku	RIV/61389013:_____/11:00359220
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	PHEG and copolymers; poly(alpha-amino acid)s; hydrogels (en)
http://linked.open.../riv/klicoveSlovo	hydrogels PHEG and copolymers poly(alpha-amino acid)s
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[FCE12654AE2D]
http://linked.open...i/riv/nazevZdroje	Journal of Materials Science-Materials in Medicine
http://linked.open...in/vavai/riv/obor	CD
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...vavai/riv/projekt	Novel soft polymer materials for tissue replacement Biodegradable hydrophilic materials for soft tissue regeneration Center for Cell Therapy and Tissue Repair
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	22
http://linked.open...iv/tvurceVysledku	Studenovská, Hana Rypáček, František Sedlačík, Tomáš
http://linked.open...ain/vavai/riv/wos	000290044000004
http://linked.open...n/vavai/riv/zamer	Progresivní makromolekulární materiály a supramolekulární systémy: syntéza a studium vlastností, jevů a možností využití pro speciální aplikace a moderní technologie
issn	0957-4530
number of pages	8 (xsd:int)
http://bibframe.org/vocab/doi	10.1007/s10856-011-4275-x
is http://linked.open...avai/riv/vysledek of	Enzymatic degradation of the hydrogels based on synthetic poly(.alpha.-amino acid)s Enzymatic degradation of the hydrogels based on synthetic poly(.alpha.-amino acid)s

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