About: Quantification in MALDI-TOF mass spectrometry of modified polymers

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	MALDI-TOF MS quantification is hampered by the poor reproducibility and molecular-mass and compositional discrimination. The use of an internal standard increases reproducibility and allows a calibration curve to be constructed. With synthetic polymers, the method requires a polymer of the same molecular mass distribution and composition as the analyte. When the content of the precursor polymer in a modified polymer is sought, the pure precursor is usually available and the modified polymer can serve as an internal standard. The method has to be combined with that of standard addition and the precursor polymer added directly to the sample. The experiments with simulated modified polymers revealed the signal-intensity ratio not proportional to the concentrations ratio. Thus, the basic assumption of the standard-addition method is not met. Therefore, the multi-point combined internal-standard standard-addition method based on the power-type calibration curve was developed and verified. MALDI-TOF MS quantification is hampered by the poor reproducibility and molecular-mass and compositional discrimination. The use of an internal standard increases reproducibility and allows a calibration curve to be constructed. With synthetic polymers, the method requires a polymer of the same molecular mass distribution and composition as the analyte. When the content of the precursor polymer in a modified polymer is sought, the pure precursor is usually available and the modified polymer can serve as an internal standard. The method has to be combined with that of standard addition and the precursor polymer added directly to the sample. The experiments with simulated modified polymers revealed the signal-intensity ratio not proportional to the concentrations ratio. Thus, the basic assumption of the standard-addition method is not met. Therefore, the multi-point combined internal-standard standard-addition method based on the power-type calibration curve was developed and verified. (en)
Title	Quantification in MALDI-TOF mass spectrometry of modified polymers Quantification in MALDI-TOF mass spectrometry of modified polymers (en)
skos:prefLabel	Quantification in MALDI-TOF mass spectrometry of modified polymers Quantification in MALDI-TOF mass spectrometry of modified polymers (en)
skos:notation	RIV/61389013:_____/11:00359037!RIV12-AV0-61389013
http://linked.open...avai/predkladatel	Ústav makromolekulární chemie AV ČR, v. v. i.
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA203/08/0543), Z(AV0Z40500505)
http://linked.open...iv/cisloPeriodika	1/2
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Walterová, Zuzana Horský, Jiří
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav makromolekulární chemie AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	225401
http://linked.open...ai/riv/idVysledku	RIV/61389013:_____/11:00359037
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	MALDI-TOF mass spectrometry; modified polymers; quantification (en)
http://linked.open.../riv/klicoveSlovo	MALDI-TOF mass spectrometry quantification modified polymers
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[25FB3C8543A0]
http://linked.open...i/riv/nazevZdroje	Analytica Chimica Acta
http://linked.open...in/vavai/riv/obor	CC
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	2 (xsd:int)
http://linked.open...vavai/riv/projekt	Hybrid macromolecular systems based on hydrophilic polymers and stimuli-responsive peptides
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	693
http://linked.open...iv/tvurceVysledku	Horský, Jiří Walterová, Zuzana
http://linked.open...ain/vavai/riv/wos	000290886800010
http://linked.open...n/vavai/riv/zamer	Progresivní makromolekulární materiály a supramolekulární systémy: syntéza a studium vlastností, jevů a možností využití pro speciální aplikace a moderní technologie
issn	0003-2670
number of pages	7 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.aca.2011.03.019
is http://linked.open...avai/riv/vysledek of	Quantification in MALDI-TOF mass spectrometry of modified polymers Quantification in MALDI-TOF mass spectrometry of modified polymers

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