About: Single-step electrospinning to bioactive polymer nanofibers

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	A single-step process to get polymer nanofiber meshes of biofunctional peptide segments is described in the article. A standard electrospinning of a homogeneous mixture of a polymer-peptide conjugate (poly(lactic acid)-block-CGGRGDS) and a biocompatible commodity poly(lactic-co-glycolic acid) (PLGA) leads to nonwovens with the peptide part enriched on the fiber surface. The accessibility of the peptide is proved by contact angle measurements as well as by probing electrostatic interaction between CGGRGDS surface functionalities and a colloidal silica probe via AFM. Bioavailability and bioactivity tests on the fiber surface demonstrate that the meshes promote adhesion and migration of fibroblasts in comparison to pure PLGA meshes. The one-step production of PLGA-based fibers could be exploited to electrospin into living cell culture without indication of toxic adverse effects on cell proliferation. This might be useful for production of cell-loaded scaffolds or biohybrid materials. A single-step process to get polymer nanofiber meshes of biofunctional peptide segments is described in the article. A standard electrospinning of a homogeneous mixture of a polymer-peptide conjugate (poly(lactic acid)-block-CGGRGDS) and a biocompatible commodity poly(lactic-co-glycolic acid) (PLGA) leads to nonwovens with the peptide part enriched on the fiber surface. The accessibility of the peptide is proved by contact angle measurements as well as by probing electrostatic interaction between CGGRGDS surface functionalities and a colloidal silica probe via AFM. Bioavailability and bioactivity tests on the fiber surface demonstrate that the meshes promote adhesion and migration of fibroblasts in comparison to pure PLGA meshes. The one-step production of PLGA-based fibers could be exploited to electrospin into living cell culture without indication of toxic adverse effects on cell proliferation. This might be useful for production of cell-loaded scaffolds or biohybrid materials. (en)
Title	Single-step electrospinning to bioactive polymer nanofibers Single-step electrospinning to bioactive polymer nanofibers (en)
skos:prefLabel	Single-step electrospinning to bioactive polymer nanofibers Single-step electrospinning to bioactive polymer nanofibers (en)
skos:notation	RIV/61389013:_____/11:00358513!RIV12-AV0-61389013
http://linked.open...avai/predkladatel	Ústav makromolekulární chemie AV ČR, v. v. i.
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(AV0Z40500505)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Černoch, Peter
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav makromolekulární chemie AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	229556
http://linked.open...ai/riv/idVysledku	RIV/61389013:_____/11:00358513
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	electrospinning; polymer-peptide conjugate; block copolymer (en)
http://linked.open.../riv/klicoveSlovo	electrospinning block copolymer polymer-peptide conjugate
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[68D78AC11C62]
http://linked.open...i/riv/nazevZdroje	Macromolecules
http://linked.open...in/vavai/riv/obor	CD
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	44
http://linked.open...iv/tvurceVysledku	Černoch, Peter Börner, H. G. Gentsch, R. Pippig, F. Polleux, J. Schmidt, S.
http://linked.open...ain/vavai/riv/wos	000286691500007
http://linked.open...n/vavai/riv/zamer	Progresivní makromolekulární materiály a supramolekulární systémy: syntéza a studium vlastností, jevů a možností využití pro speciální aplikace a moderní technologie
issn	0024-9297
number of pages	9 (xsd:int)
http://bibframe.org/vocab/doi	10.1021/ma102847a
is http://linked.open...avai/riv/vysledek of	Single-step electrospinning to bioactive polymer nanofibers Single-step electrospinning to bioactive polymer nanofibers

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