About: Simvastatin: structure solution of two new low-temperature phases from synchrotron powder diffraction and ss-NMR

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Simvastatin is an active pharmaceutical ingredient generally used for the treatment of hypercholesterolemia. In addition to the already known room-temperature structure of simvastatin, two new low-temperature polymorphs were found with the phase transition at 272 and 232 K. The main structural differences between these three polymorphs consist in the side-chains conformation. The observed phase transformations are fully reversible. The structures of the polymorphs were studied by the powder diffraction based on synchrotron radiation as well as by solid-state NMR spectroscopy. Simvastatin is an active pharmaceutical ingredient generally used for the treatment of hypercholesterolemia. In addition to the already known room-temperature structure of simvastatin, two new low-temperature polymorphs were found with the phase transition at 272 and 232 K. The main structural differences between these three polymorphs consist in the side-chains conformation. The observed phase transformations are fully reversible. The structures of the polymorphs were studied by the powder diffraction based on synchrotron radiation as well as by solid-state NMR spectroscopy. (en)
Title	Simvastatin: structure solution of two new low-temperature phases from synchrotron powder diffraction and ss-NMR Simvastatin: structure solution of two new low-temperature phases from synchrotron powder diffraction and ss-NMR (en)
skos:prefLabel	Simvastatin: structure solution of two new low-temperature phases from synchrotron powder diffraction and ss-NMR Simvastatin: structure solution of two new low-temperature phases from synchrotron powder diffraction and ss-NMR (en)
skos:notation	RIV/61389013:_____/10:00343202!RIV11-MSM-61389013
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(2B08021), P(IAA400500602), Z(AV0Z40500505), Z(MSM6046137302)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Brus, Jiří
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav makromolekulární chemie AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	287529
http://linked.open...ai/riv/idVysledku	RIV/61389013:_____/10:00343202
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	crystal structure; simvastatin; powder diffraction (en)
http://linked.open.../riv/klicoveSlovo	powder diffraction crystal structure simvastatin
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[5E529C96AFE3]
http://linked.open...i/riv/nazevZdroje	Structural Chemistry
http://linked.open...in/vavai/riv/obor	CD
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Development and application of solid-state NMR techniques to measure dipolar couplings - determination of three-dimensional structure and amplitude of internal motions in microcrystalline and highly organized self-assembled polymer systems. NMR crystallography of active pharmaceuticals ingredients for industrial applications
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	21
http://linked.open...iv/tvurceVysledku	Kratochvíl, B. Maixner, J. Brus, Jiří Hušák, M. Jegorov, A. Rohlíček, J.
http://linked.open...ain/vavai/riv/wos	000277377500007
http://linked.open...n/vavai/riv/zamer	Progresivní makromolekulární materiály a supramolekulární systémy: syntéza a studium vlastností, jevů a možností využití pro speciální aplikace a moderní technologie Preparation and research of functional materials and material technologies using micro- and nanoscopic methods
issn	1040-0400
number of pages	8 (xsd:int)
is http://linked.open...avai/riv/vysledek of	Simvastatin: structure solution of two new low-temperature phases from synchrotron powder diffraction and ss-NMR Simvastatin: structure solution of two new low-temperature phases from synchrotron powder diffraction and ss-NMR Simvastatin: structure solution of two new low-temperature phases from synchrotron powder diffraction and ss-NMR

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