About: Virotherapy of ovarian cancer with polymer-cloaked adenovirus retargeted to the epidermal growth factor receptor     Goto   Sponge   NotDistinct   Permalink

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Description
  • Normal virus tropism can be ablated by physically shielding the virus surface with reactive hydrophilic polymers and that linkage of novel ligands enables virus retargeting through chosen receptors. The resulting mEGF-polymer coated adenovirus lost its normal broad tropism and transduced cells selectively via the EGF receptor (EGFR).
  • Normal virus tropism can be ablated by physically shielding the virus surface with reactive hydrophilic polymers and that linkage of novel ligands enables virus retargeting through chosen receptors. The resulting mEGF-polymer coated adenovirus lost its normal broad tropism and transduced cells selectively via the EGF receptor (EGFR). (en)
  • Běžný virální tropismus může být potlačen modifikací povrchu viru reaktivními hydrofilními polymery, které zároveň zavádějí nové specifické ligandy, a tím umožňují retargeting k zvoleným receptorům. Adenovirus modifikovaný polymerem s mEGF ztratil svůj široký tropismus a infikoval buňky selektivně přes EGF receptory (EGFR). (cs)
Title
  • Virotherapy of ovarian cancer with polymer-cloaked adenovirus retargeted to the epidermal growth factor receptor
  • Virální terapie rakoviny ovarií polymerem modifikovaným adenovirem směrovaným k receptorům epidermálního růstového faktoru (cs)
  • Virotherapy of ovarian cancer with polymer-cloaked adenovirus retargeted to the epidermal growth factor receptor (en)
skos:prefLabel
  • Virotherapy of ovarian cancer with polymer-cloaked adenovirus retargeted to the epidermal growth factor receptor
  • Virální terapie rakoviny ovarií polymerem modifikovaným adenovirem směrovaným k receptorům epidermálního růstového faktoru (cs)
  • Virotherapy of ovarian cancer with polymer-cloaked adenovirus retargeted to the epidermal growth factor receptor (en)
skos:notation
  • RIV/61389013:_____/08:00311069!RIV09-AV0-61389013
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • Z(AV0Z40500505)
http://linked.open...iv/cisloPeriodika
  • 2
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 402721
http://linked.open...ai/riv/idVysledku
  • RIV/61389013:_____/08:00311069
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • adenovirus; gene delivery; N-(2-hydroxypropyl)methacrylamide (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • US - Spojené státy americké
http://linked.open...ontrolniKodProRIV
  • [64B7A51FAD41]
http://linked.open...i/riv/nazevZdroje
  • Molecular Therapy
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 16
http://linked.open...iv/tvurceVysledku
  • Ulbrich, Karel
  • Seymour, L. W.
  • Šubr, Vladimír
  • Green, N.
  • Fisher, K.
  • Briggs, S. S.
  • Morrison, J.
  • Kehoe, S.
http://linked.open...ain/vavai/riv/wos
  • 252748600004
http://linked.open...n/vavai/riv/zamer
issn
  • 1525-0016
number of pages
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