About: Investigation of nanoparticle coating by fluorescence correlation spectroscopy

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Výzkum nanočástic ve fluorescenční korelační spektroskopii. (cs) Protecting gene delivery vectors by hydrophilic copolymer coating is a promising approach in targeted gene therapy. Herein we demonstrate the usefulness of FCS in characterizing the coating process of a virus model - latex beads with coumarin-labeled N-(2-hydroxypropyl)methacrylamide copolymer containing thiazolidine-2-thione groups. FCS gives an estimation of the average number of polymer chains coating the latex bead, which agrees with light scattering results, giving an evidence of quality of the vector surface modification. FCS is advantageous because it decreases the sample consumption by a factor of 1 000. The coumarin label showed advantages over the previously used fluorescein-based one. Protecting gene delivery vectors by hydrophilic copolymer coating is a promising approach in targeted gene therapy. Herein we demonstrate the usefulness of FCS in characterizing the coating process of a virus model - latex beads with coumarin-labeled N-(2-hydroxypropyl)methacrylamide copolymer containing thiazolidine-2-thione groups. FCS gives an estimation of the average number of polymer chains coating the latex bead, which agrees with light scattering results, giving an evidence of quality of the vector surface modification. FCS is advantageous because it decreases the sample consumption by a factor of 1 000. The coumarin label showed advantages over the previously used fluorescein-based one. (en)
Title	Investigation of nanoparticle coating by fluorescence correlation spectroscopy Výzkum nanočástic ve fluorescenční korelační spektroskopii (cs) Investigation of nanoparticle coating by fluorescence correlation spectroscopy (en)
skos:prefLabel	Investigation of nanoparticle coating by fluorescence correlation spectroscopy Výzkum nanočástic ve fluorescenční korelační spektroskopii (cs) Investigation of nanoparticle coating by fluorescence correlation spectroscopy (en)
skos:notation	RIV/61389013:_____/08:00311010!RIV09-AV0-61389013
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(IAA100500501), P(IAA4050403), P(KAN200200651), Z(AV0Z40400503), Z(AV0Z40500505)
http://linked.open...iv/cisloPeriodika	14
http://linked.open...vai/riv/dodaniDat	2009
http://linked.open...aciTvurceVysledku	Štěpánek, Petr Ulbrich, Karel Šubr, Vladimír Koňák, Čestmír
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav makromolekulární chemie AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	373212
http://linked.open...ai/riv/idVysledku	RIV/61389013:_____/08:00311010
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	coatings; drug delivery systems; fluorescence; light scattering (en)
http://linked.open.../riv/klicoveSlovo	fluorescence light scattering drug delivery systems coatings
http://linked.open...odStatuVydavatele	DE - Spolková republika Německo
http://linked.open...ontrolniKodProRIV	[229E235EC546]
http://linked.open...i/riv/nazevZdroje	Macromolecular Chemistry and Physics
http://linked.open...in/vavai/riv/obor	CF
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Nanoparticulate and supramolecular systems for targeted drug delivery Environment-responsive nanoparticles Self-organization of hydrophobic polymers with ionizable groups
http://linked.open...UplatneniVysledku	2008
http://linked.open...v/svazekPeriodika	209
http://linked.open...iv/tvurceVysledku	Hof, Martin Jurkiewicz, Piotr Ulbrich, Karel Štěpánek, Petr Šubr, Vladimír Koňák, Čestmír
http://linked.open...ain/vavai/riv/wos	000258282400005
http://linked.open...n/vavai/riv/zamer	Struktura, reaktivita a dynamika molekulárních a biomolekulárních systémů: teorie, experiment, aplikace Progresivní makromolekulární materiály a supramolekulární systémy: syntéza a studium vlastností, jevů a možností využití pro speciální aplikace a moderní technologie
issn	1022-1352
number of pages	7 (xsd:int)
is http://linked.open...avai/riv/vysledek of	Investigation of nanoparticle coating by fluorescence correlation spectroscopy Investigation of nanoparticle coating by fluorescence correlation spectroscopy Investigation of nanoparticle coating by fluorescence correlation spectroscopy Investigation of nanoparticle coating by fluorescence correlation spectroscopy

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