About: Novel synthesis of HPMA copolymers containing peptide grafts and their self-assembly into hybrid hydrogels

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Byl vyvinut nový způsob syntézy roubovaných kopolymerů HPMA a byla studována jejich asociace do hybridních hydrogelů. Lineární vodorozpustný polyHPMA byl vybrán jako polymerní nosič a “coiled-coil“ peptidy byly k němu kovalentně vázány a tvořily tzv. rouby. Pro výzkum byly použity peptidy různých délek. Výsledky ukázaly, že schopnost gelace polymerů je silně ovlivněna délkou roubů. (cs) A new pathway for the synthesis of HPMA graft copolymers was developed and their self-assembly into hybrid hydrogels was investigated. Linear water-soluble polyHPMA was chosen as the polymer backbone, whereas coiled-coil forming peptides, covalently attached to the backbone, formed the grafts. Peptides of different chain lengths were chosen for evaluation. The results revealed that graft length greatly affected gelation ability. A new pathway for the synthesis of HPMA graft copolymers was developed and their self-assembly into hybrid hydrogels was investigated. Linear water-soluble polyHPMA was chosen as the polymer backbone, whereas coiled-coil forming peptides, covalently attached to the backbone, formed the grafts. Peptides of different chain lengths were chosen for evaluation. The results revealed that graft length greatly affected gelation ability. (en)
Title	Novel synthesis of HPMA copolymers containing peptide grafts and their self-assembly into hybrid hydrogels Novel synthesis of HPMA copolymers containing peptide grafts and their self-assembly into hybrid hydrogels (en) Nová syntéza HPMA kopolymerů obsahujících peptidové rouby a jejich asociace do hybridních gelů (cs)
skos:prefLabel	Novel synthesis of HPMA copolymers containing peptide grafts and their self-assembly into hybrid hydrogels Novel synthesis of HPMA copolymers containing peptide grafts and their self-assembly into hybrid hydrogels (en) Nová syntéza HPMA kopolymerů obsahujících peptidové rouby a jejich asociace do hybridních gelů (cs)
skos:notation	RIV/61389013:_____/08:00306827!RIV08-AV0-61389013
http://linked.open.../vavai/riv/strany	467;475
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GESON/06/E005), Z(AV0Z40500505)
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2008
http://linked.open...aciTvurceVysledku	Koňák, Čestmír
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav makromolekulární chemie AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	383285
http://linked.open...ai/riv/idVysledku	RIV/61389013:_____/08:00306827
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	coiled-coils; graft copolymers; HPMA copolymers (en)
http://linked.open.../riv/klicoveSlovo	graft copolymers HPMA copolymers coiled-coils
http://linked.open...odStatuVydavatele	DE - Spolková republika Německo
http://linked.open...ontrolniKodProRIV	[BE08F0889250]
http://linked.open...i/riv/nazevZdroje	Macromolecular Chemistry and Physics
http://linked.open...in/vavai/riv/obor	CD
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Biofunctional Selforganized Nano-Structures of Ionic/Non Ionic Amphiphilic Copolymers, Biopolymers-Biomacromolecules and Nanoparticles: From Bioinspired to Bioi
http://linked.open...UplatneniVysledku	2008
http://linked.open...v/svazekPeriodika	209
http://linked.open...iv/tvurceVysledku	Kopeček, J. Koňák, Čestmír Wu, K. Kopečková, P. Yang, J.
http://linked.open...n/vavai/riv/zamer	Progresivní makromolekulární materiály a supramolekulární systémy: syntéza a studium vlastností, jevů a možností využití pro speciální aplikace a moderní technologie
issn	1022-1352
number of pages	9 (xsd:int)
is http://linked.open...avai/riv/vysledek of	Novel synthesis of HPMA copolymers containing peptide grafts and their self-assembly into hybrid hydrogels Novel synthesis of HPMA copolymers containing peptide grafts and their self-assembly into hybrid hydrogels Novel synthesis of HPMA copolymers containing peptide grafts and their self-assembly into hybrid hydrogels Novel synthesis of HPMA copolymers containing peptide grafts and their self-assembly into hybrid hydrogels

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