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Description
  • Systemická aplikace adenovirálních vektorů je jedním z hlavních cílů genové terapie. Technika maskování povrchu multivalentním HPMA kopolymerem byla užita k odstranění všech cest receptorem zprostředkované infekce. Maskování polymerem vedlo k přinejmenším 100násobnému poklesu nežádoucí hepatické transgenické exprese a vyústilo v prodlouženou cirkulaci v krvi a zlepšenou biologickou dostupnost adenoviru. (cs)
  • Systemic delivery of adenoviral vectors is a major goal in cancer gene therapy. Surface-masking technique based on multivalent HPMA copolymers was used to ablate all pathways of receptor-mediated infection. Polymer coating of adenovirus gave at least 100-fold decreased unwanted hepatic transgene expression and resulted in prolonged blood circulation and improved bioavailability of the adenovirus.
  • Systemic delivery of adenoviral vectors is a major goal in cancer gene therapy. Surface-masking technique based on multivalent HPMA copolymers was used to ablate all pathways of receptor-mediated infection. Polymer coating of adenovirus gave at least 100-fold decreased unwanted hepatic transgene expression and resulted in prolonged blood circulation and improved bioavailability of the adenovirus. (en)
Title
  • Extended plasma circulation time and decreased toxicity of polymer-coated adenovirus
  • Prodloužená doba cirkulace v plazmě a snížená toxicita polymerem krytých adenovirů (cs)
  • Extended plasma circulation time and decreased toxicity of polymer-coated adenovirus (en)
skos:prefLabel
  • Extended plasma circulation time and decreased toxicity of polymer-coated adenovirus
  • Prodloužená doba cirkulace v plazmě a snížená toxicita polymerem krytých adenovirů (cs)
  • Extended plasma circulation time and decreased toxicity of polymer-coated adenovirus (en)
skos:notation
  • RIV/61389013:_____/04:00101438!RIV/2005/AV0/A55005/N
http://linked.open.../vavai/riv/strany
  • 1256;1263
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(KSK4055109), Z(AV0Z4050913)
http://linked.open...iv/cisloPeriodika
  • 16
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 563943
http://linked.open...ai/riv/idVysledku
  • RIV/61389013:_____/04:00101438
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • adenovirus;gene delivery;polymer coating (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • US - Spojené státy americké
http://linked.open...ontrolniKodProRIV
  • [3B5E64FBA43F]
http://linked.open...i/riv/nazevZdroje
  • Gene Therapy
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 11
http://linked.open...iv/tvurceVysledku
  • Ulbrich, Karel
  • Fisher, K. D.
  • Seymour, L. W.
  • Green, N. K.
  • Hermiston, T.
  • Mautner, V.
  • Hale, S. J.
  • Hale, A. B.
  • Harkins, R.
  • Herbert, C. W.
http://linked.open...n/vavai/riv/zamer
issn
  • 0969-7128
number of pages
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